Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird

Charlotte Récapet; Adélaïde Sibeaux; Laure Cauchard; Blandine Doligez; Pierre Bize

doi:10.1098/rsbl.2016.0243

Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird

Charlotte Récapet
, Adélaïde Sibeaux
, Laure Cauchard
, Blandine Doligez
, Pierre Bize

Aberdeen Centre For Environmental Sustainability

Universite Claude Bernard Lyon 1
University of Lausanne
University of Montreal
Uppsala University

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

18 Downloads (Pure)

Abstract

Although disruption of glucose homeostasis is a hallmark of ageing in humans and laboratory model organisms, we have little information on the importance of this process in free-living animals. Poor control of blood glucose levels leads to irreversible protein glycation. Hence, levels of protein glycation are hypothesized to increase with age and to be associated with a decline in survival. We tested these predictions by measuring blood glycated haemoglobin in 274 adult collared flycatchers of known age and estimating individual probability of recapture in the following 2 years. Results show a strong decrease in glycated haemoglobin from age 1 to 5 years and an increase thereafter. Individuals with high levels of glycated haemoglobin had a lower probability of recapture, even after controlling for effects of age and dispersal. Altogether, our findings suggest that poor control of glucose homoeostasis is associated with lower survival in this free-living bird population, and that the selective disappearance of individuals with the highest glycation levels could account for the counterintuitive age-related decline in glycated haemoglobin in the early age categories.

Original language	English
Article number	20160243
Number of pages	5
Journal	Biology Letters
Volume	12
Issue number	8
Early online date	1 Aug 2016
DOIs	https://doi.org/10.1098/rsbl.2016.0243
Publication status	Published - 31 Aug 2016

Bibliographical note

This work was supported by the ANR (ANR-06-JCJC0082 to
B.D.), the CNRS (PEPS INEE and PICS France–Switzerland to B.D.),
the French Ministe`re de l’Enseignement Supe´rieur et de la Recherche (PhD fellowship to C.R.), the Re´gion Rhoˆne-Alpes (Explora’doc mobility grant to C.R.), the University of Aberdeen (stipend to C.R.), the L’Ore´al Foundation-UNESCO ‘For Women in Science’ program (fellowship to C.R.) and the Rectors’ Conference of the Swiss Universities (grant to C.R. and P.B.).

Funding

This work was supported by the ANR (ANR-06-JCJC0082 to B.D.), the CNRS (PEPS INEE and PICS France-Switzerland to B.D.), the French Ministere de l'Enseignement Superieur et de la Recherche (PhD fellowship to C.R.), the Region Rhone-Alpes (Explora'doc mobility grant to C.R.), the University of Aberdeen (stipend to C.R.), the L'Oreal Foundation-UNESCO 'For Women in Science' program (fellowship to C.R.) and the Rectors' Conference of the Swiss Universities (grant to C.R. and P.B.).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ageing
diabetes
glycation
survival
collared flycatcher
Ficedula albicollis
SENESCENCE
AGE
POPULATIONS
DISPERSAL
MODEL

Access to Document

10.1098/rsbl.2016.0243Licence: Unspecified

Accepted ManuscriptAccepted author manuscript, 352 KBLicence: Unspecified

Data from: Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird
Récapet, C. (Creator), Sibeaux, A. (Creator), Cauchard, L. (Creator), Doligez, B. (Creator), Bize, P. (Creator) & Paton, G. (Data Manager), Dryad Digital Repository, 23 May 2016
DOI: 10.5061/dryad.87035
Dataset

Cite this

@article{5bec935c19c64531a6a9f3ea1f9c0023,

title = "Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird",

abstract = "Although disruption of glucose homeostasis is a hallmark of ageing in humans and laboratory model organisms, we have little information on the importance of this process in free-living animals. Poor control of blood glucose levels leads to irreversible protein glycation. Hence, levels of protein glycation are hypothesized to increase with age and to be associated with a decline in survival. We tested these predictions by measuring blood glycated haemoglobin in 274 adult collared flycatchers of known age and estimating individual probability of recapture in the following 2 years. Results show a strong decrease in glycated haemoglobin from age 1 to 5 years and an increase thereafter. Individuals with high levels of glycated haemoglobin had a lower probability of recapture, even after controlling for effects of age and dispersal. Altogether, our findings suggest that poor control of glucose homoeostasis is associated with lower survival in this free-living bird population, and that the selective disappearance of individuals with the highest glycation levels could account for the counterintuitive age-related decline in glycated haemoglobin in the early age categories.",

keywords = "ageing, diabetes, glycation, survival, collared flycatcher, Ficedula albicollis, SENESCENCE, AGE, POPULATIONS, DISPERSAL, MODEL",

author = "Charlotte R{\'e}capet and Ad{\'e}la{\"i}de Sibeaux and Laure Cauchard and Blandine Doligez and Pierre Bize",

note = "This work was supported by the ANR (ANR-06-JCJC0082 to B.D.), the CNRS (PEPS INEE and PICS France{\textendash}Switzerland to B.D.), the French Ministe`re de l{\textquoteright}Enseignement Supe´rieur et de la Recherche (PhD fellowship to C.R.), the Re´gion Rhoˆne-Alpes (Explora{\textquoteright}doc mobility grant to C.R.), the University of Aberdeen (stipend to C.R.), the L{\textquoteright}Ore´al Foundation-UNESCO {\textquoteleft}For Women in Science{\textquoteright} program (fellowship to C.R.) and the Rectors{\textquoteright} Conference of the Swiss Universities (grant to C.R. and P.B.).",

year = "2016",

month = aug,

day = "31",

doi = "10.1098/rsbl.2016.0243",

language = "English",

volume = "12",

journal = "Biology Letters",

issn = "1744-9561",

publisher = "The Royal Society",

number = "8",

}

TY - JOUR

T1 - Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird

AU - Récapet, Charlotte

AU - Sibeaux, Adélaïde

AU - Cauchard, Laure

AU - Doligez, Blandine

AU - Bize, Pierre

N1 - This work was supported by the ANR (ANR-06-JCJC0082 to B.D.), the CNRS (PEPS INEE and PICS France–Switzerland to B.D.), the French Ministe`re de l’Enseignement Supe´rieur et de la Recherche (PhD fellowship to C.R.), the Re´gion Rhoˆne-Alpes (Explora’doc mobility grant to C.R.), the University of Aberdeen (stipend to C.R.), the L’Ore´al Foundation-UNESCO ‘For Women in Science’ program (fellowship to C.R.) and the Rectors’ Conference of the Swiss Universities (grant to C.R. and P.B.).

PY - 2016/8/31

Y1 - 2016/8/31

N2 - Although disruption of glucose homeostasis is a hallmark of ageing in humans and laboratory model organisms, we have little information on the importance of this process in free-living animals. Poor control of blood glucose levels leads to irreversible protein glycation. Hence, levels of protein glycation are hypothesized to increase with age and to be associated with a decline in survival. We tested these predictions by measuring blood glycated haemoglobin in 274 adult collared flycatchers of known age and estimating individual probability of recapture in the following 2 years. Results show a strong decrease in glycated haemoglobin from age 1 to 5 years and an increase thereafter. Individuals with high levels of glycated haemoglobin had a lower probability of recapture, even after controlling for effects of age and dispersal. Altogether, our findings suggest that poor control of glucose homoeostasis is associated with lower survival in this free-living bird population, and that the selective disappearance of individuals with the highest glycation levels could account for the counterintuitive age-related decline in glycated haemoglobin in the early age categories.

AB - Although disruption of glucose homeostasis is a hallmark of ageing in humans and laboratory model organisms, we have little information on the importance of this process in free-living animals. Poor control of blood glucose levels leads to irreversible protein glycation. Hence, levels of protein glycation are hypothesized to increase with age and to be associated with a decline in survival. We tested these predictions by measuring blood glycated haemoglobin in 274 adult collared flycatchers of known age and estimating individual probability of recapture in the following 2 years. Results show a strong decrease in glycated haemoglobin from age 1 to 5 years and an increase thereafter. Individuals with high levels of glycated haemoglobin had a lower probability of recapture, even after controlling for effects of age and dispersal. Altogether, our findings suggest that poor control of glucose homoeostasis is associated with lower survival in this free-living bird population, and that the selective disappearance of individuals with the highest glycation levels could account for the counterintuitive age-related decline in glycated haemoglobin in the early age categories.

KW - ageing

KW - diabetes

KW - glycation

KW - survival

KW - collared flycatcher

KW - Ficedula albicollis

KW - SENESCENCE

KW - AGE

KW - POPULATIONS

KW - DISPERSAL

KW - MODEL

U2 - 10.1098/rsbl.2016.0243

DO - 10.1098/rsbl.2016.0243

M3 - Article

SN - 1744-9561

VL - 12

JO - Biology Letters

JF - Biology Letters

IS - 8

M1 - 20160243

ER -

Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Fingerprint

Datasets

Data from: Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird

Cite this