Smoking does not protect patients with axial spondyloarthritis from attacks of uveitis

Sizheng Steven Zhao, Gary J Macfarlane, Gareth T Jones, Karl Gaffney, David M Hughes, Robert J Moots, Nicola J Goodson* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Acute anterior uveitis (AAU) is the the most common extra-axial manifestation in axial spondyloarthritis (axSpA) and can lead to visual impairment if untreated. Cross-sectional axSpA studies have consistently reported lower odds of AAU in current smokers than ex or never smokers,1 2 which is in contrast to higher AAU risk among smokers in the general population.3 One explanation for this apparent paradox is behaviour change; those with AAU may be more likely to quit smoking. However, this does not explain the higher odds of AAU in never smokers. Another possibility is that smoking is protective for AAU as it is for ulcerative colitis, which shares patho-aetiology with axSpA and AAU.4 If smoking is protective of AAU, it should also reduce the frequency of flares. We examined the impact of smoking status on the number of AAU episodes among patients with AAU.
Original languageEnglish
Pages (from-to)1287-1288
Number of pages2
JournalAnnals of the Rheumatic Diseases
Issue number9
Early online date20 Apr 2019
Publication statusPublished - Sept 2019

Bibliographical note

The BSRBR-AS is funded by the British Society for Rheumatology (BSR) who have received funding for this from Pfizer, AbbVie and UCB.


  • ankylosing spondylitis
  • axial spondyloarthritis
  • smoking
  • uveitis


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