Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy

Jonathan Duncan; C Horrocks; Anthony Ormerod; A V Powles; P H Whiting; L Fry; A W Thomson

doi:10.1111/j.1365-2249.1991.tb05721.x

Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy

Jonathan Duncan
, C Horrocks
, Anthony Ormerod
, A V Powles
, P H Whiting
, L Fry
, A W Thomson

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.

Original language	English
Pages (from-to)	293-296
Number of pages	4
Journal	Clinical and Experimental Immunology
Volume	85
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2249.1991.tb05721.x
Publication status	Published - 1 Aug 1991

Keywords

Adult
Cyclosporins
Humans
PUVA Therapy
Psoriasis
Receptors, Interleukin-2
T-Lymphocytes

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10.1111/j.1365-2249.1991.tb05721.x

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title = "Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy",

abstract = "A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.",

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AU - Ormerod, Anthony

AU - Powles, A V

AU - Whiting, P H

AU - Fry, L

AU - Thomson, A W

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AB - A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.

KW - Adult

KW - Cyclosporins

KW - Humans

KW - PUVA Therapy

KW - Psoriasis

KW - Receptors, Interleukin-2

KW - T-Lymphocytes

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JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

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ER -

Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy

Abstract

Keywords

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