Sponge-associated fungi and their bioactive compounds: The Suberites case

P. Proksch, R. Ebel, R. Edrada, F. Riebe, H. Liu, A. Diesel, M. Bayer, X. Li, W. Han Lin, V. Grebenyuk, W.E.G. Müller, S. Draeger, A. Zuccaro, B. Schulz

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Specimens of Suberites domuncula that had been cultured in aquaria for 4 weeks were analyzed for their associated fungi. A total of 81 fungal strains belonging to 20 different genera was isolated and identified by morphological and molecular methods. The most frequently isolated taxa were Cladosporium spp., Penicillium spp., Petriella sp., Phialophora spp. and Engyodontium album. Based on chromatographic and mass spectrometric analysis of fungal extracts, as well as on bioassay results, Aspergillus ustus, Penicillium sp., Petriella sp. and Scopulariopsis sp. were selected for in-depth analysis of their natural products. A total of 19 different fungal metabolites, including three new natural products, was isolated and structurally identified. A. ustus yielded two sesquiterpenes, a drimane derivative and deoxyuvidin, as well as a sesterterpene ophiobolin H. The drimane derivative had an ED value against L5178Y cells of 1.9 µg ml in vitro. The crude extract of Petriella sp. was also strongly cytotoxic against the L5178Y cell line. The cyclic tetrapeptide WF-3161 was primarily responsible for the activity; the ED value was
Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalBotanica Marina
Issue number3
Publication statusPublished - Mar 2008


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