18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Elisa Calamai; Sergio Dall'Angelo; David Koss; Juozas Domarkas; Timothy J McCarthy; Marco Mingarelli; Gernot Riedel; Lutz Frank Schweiger; Andrew Edward Welch; Bettina Platt; Matteo Zanda

doi:10.1039/C2CC38443D

¹⁸F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Elisa Calamai
, Sergio Dall'Angelo
, David Koss
, Juozas Domarkas
, Timothy J McCarthy
, Marco Mingarelli
, Gernot Riedel
, Lutz Frank Schweiger
, Andrew Edward Welch
, Bettina Platt
, Matteo Zanda

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [¹⁸F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [¹⁸F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

Original language	English
Pages (from-to)	792-794
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	8
Early online date	4 Dec 2012
DOIs	https://doi.org/10.1039/C2CC38443D https://doi.org/10.1039/c2cc38443d
Publication status	Published - 2013

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title = "18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease",

abstract = "Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.",

author = "Elisa Calamai and Sergio Dall'Angelo and David Koss and Juozas Domarkas and McCarthy, \{Timothy J\} and Marco Mingarelli and Gernot Riedel and Schweiger, \{Lutz Frank\} and Welch, \{Andrew Edward\} and Bettina Platt and Matteo Zanda",

year = "2013",

doi = "10.1039/C2CC38443D",

language = "English",

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journal = "Chemical Communications",

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T1 - 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

AU - Calamai, Elisa

AU - Dall'Angelo, Sergio

AU - Koss, David

AU - Domarkas, Juozas

AU - McCarthy, Timothy J

AU - Mingarelli, Marco

AU - Riedel, Gernot

AU - Schweiger, Lutz Frank

AU - Welch, Andrew Edward

AU - Platt, Bettina

AU - Zanda, Matteo

PY - 2013

Y1 - 2013

N2 - Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

AB - Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [18F]1a, was synthesised in radiofluorinated form. PET/CT Imaging with [18F]1a identified β-amyloid over-expressing transgenic mice (βA mice) compared to wild type and tau lines. The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator.

U2 - 10.1039/C2CC38443D

DO - 10.1039/C2CC38443D

M3 - Article

C2 - 23235438

SN - 1359-7345

VL - 49

SP - 792

EP - 794

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

Abstract

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¹⁸F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease