Superinfection with human immunodeficiency virus type 2 can reactivate virus production in baboons but is contained by a CD8 T cell antiviral response

Christopher P. Locher; David J. Blackbourn; Susan W. Barnett; Krishna K. Murthy; Elizabeth K. Cobb; Scott Rouse; Giampaolo Greco; Gustavo Reyes-Terán; Kathleen M. Brasky; Kenneth D. Carey; Jay A. Levy

doi:10.1086/516544

Superinfection with human immunodeficiency virus type 2 can reactivate virus production in baboons but is contained by a CD8 T cell antiviral response

Christopher P. Locher
, David J. Blackbourn
, Susan W. Barnett
, Krishna K. Murthy
, Elizabeth K. Cobb
, Scott Rouse
, Giampaolo Greco
, Gustavo Reyes-Terán
, Kathleen M. Brasky
, Kenneth D. Carey
, Jay A. Levy^*

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

An animal model was used to assess whether resistance to superinfection by human immunodeficiency virus (HIV) can exist in vivo. Asymptomatic baboons (Papio cynocephalus), previously infected with HIV-2, were first challenged with homologous virus (HIV-2(UC2) or HIV-2(UC14)) and later with heterologous virus (HlV-2(UC12)). After both virus inoculations, either resistance to vital infection or a transient viremia was observed. The original virus was recovered in 3 baboons, suggesting that reactivation of a latent infection occurred an heterologous challenge and that HIV-2 superinfection is blocked by processes established during prior infection. Antibody titers measured by ELISA and virus neutralization remained at low levels. However, suppression of HIV-1 replication was observed with CD8 T cells and filtered cell culture supernatants. The soluble factor involved was not a β-chemokine. This resistance to HIV superinfection appears to be mediated at least in part by CD8 T cells that suppress virus production.

Original language	English
Pages (from-to)	948-959
Number of pages	12
Journal	Journal of Infectious Diseases
Volume	176
Issue number	4
DOIs	https://doi.org/10.1086/516544
Publication status	Published - 1997

Bibliographical note

Funding Information:
Financial support: NIH (AI-34704); postdoctoral training grant provided by the George Williams Hooper Foundation, San Francisco (C.P.L.); University of California, Universitywide AIDS Research Program (grant F94-SF-008) (D.J.B.); Fogarty International Fellowship (G.R.-T.); Istituto Superiore di San-itá, Rome (G.G).

Funding

Financial support: NIH (AI-34704); postdoctoral training grant provided by the George Williams Hooper Foundation, San Francisco (C.P.L.); University of California, Universitywide AIDS Research Program (grant F94-SF-008) (D.J.B.); Fogarty International Fellowship (G.R.-T.); Istituto Superiore di San-itá, Rome (G.G).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1086/516544

Cite this

Locher, C. P., Blackbourn, D. J., Barnett, S. W., Murthy, K. K., Cobb, E. K., Rouse, S., Greco, G., Reyes-Terán, G., Brasky, K. M., Carey, K. D., & Levy, J. A. (1997). Superinfection with human immunodeficiency virus type 2 can reactivate virus production in baboons but is contained by a CD8 T cell antiviral response. Journal of Infectious Diseases, 176(4), 948-959. https://doi.org/10.1086/516544

Locher, CP, Blackbourn, DJ, Barnett, SW, Murthy, KK, Cobb, EK, Rouse, S, Greco, G, Reyes-Terán, G, Brasky, KM, Carey, KD & Levy, JA 1997, 'Superinfection with human immunodeficiency virus type 2 can reactivate virus production in baboons but is contained by a CD8 T cell antiviral response', Journal of Infectious Diseases, vol. 176, no. 4, pp. 948-959. https://doi.org/10.1086/516544

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abstract = "An animal model was used to assess whether resistance to superinfection by human immunodeficiency virus (HIV) can exist in vivo. Asymptomatic baboons (Papio cynocephalus), previously infected with HIV-2, were first challenged with homologous virus (HIV-2(UC2) or HIV-2(UC14)) and later with heterologous virus (HlV-2(UC12)). After both virus inoculations, either resistance to vital infection or a transient viremia was observed. The original virus was recovered in 3 baboons, suggesting that reactivation of a latent infection occurred an heterologous challenge and that HIV-2 superinfection is blocked by processes established during prior infection. Antibody titers measured by ELISA and virus neutralization remained at low levels. However, suppression of HIV-1 replication was observed with CD8 T cells and filtered cell culture supernatants. The soluble factor involved was not a β-chemokine. This resistance to HIV superinfection appears to be mediated at least in part by CD8 T cells that suppress virus production.",

author = "Locher, \{Christopher P.\} and Blackbourn, \{David J.\} and Barnett, \{Susan W.\} and Murthy, \{Krishna K.\} and Cobb, \{Elizabeth K.\} and Scott Rouse and Giampaolo Greco and Gustavo Reyes-Ter{\'a}n and Brasky, \{Kathleen M.\} and Carey, \{Kenneth D.\} and Levy, \{Jay A.\}",

note = "Funding Information: Financial support: NIH (AI-34704); postdoctoral training grant provided by the George Williams Hooper Foundation, San Francisco (C.P.L.); University of California, Universitywide AIDS Research Program (grant F94-SF-008) (D.J.B.); Fogarty International Fellowship (G.R.-T.); Istituto Superiore di San-it{\'a}, Rome (G.G).",

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AU - Murthy, Krishna K.

AU - Cobb, Elizabeth K.

AU - Rouse, Scott

AU - Greco, Giampaolo

AU - Reyes-Terán, Gustavo

AU - Brasky, Kathleen M.

AU - Carey, Kenneth D.

AU - Levy, Jay A.

N1 - Funding Information: Financial support: NIH (AI-34704); postdoctoral training grant provided by the George Williams Hooper Foundation, San Francisco (C.P.L.); University of California, Universitywide AIDS Research Program (grant F94-SF-008) (D.J.B.); Fogarty International Fellowship (G.R.-T.); Istituto Superiore di San-itá, Rome (G.G).

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N2 - An animal model was used to assess whether resistance to superinfection by human immunodeficiency virus (HIV) can exist in vivo. Asymptomatic baboons (Papio cynocephalus), previously infected with HIV-2, were first challenged with homologous virus (HIV-2(UC2) or HIV-2(UC14)) and later with heterologous virus (HlV-2(UC12)). After both virus inoculations, either resistance to vital infection or a transient viremia was observed. The original virus was recovered in 3 baboons, suggesting that reactivation of a latent infection occurred an heterologous challenge and that HIV-2 superinfection is blocked by processes established during prior infection. Antibody titers measured by ELISA and virus neutralization remained at low levels. However, suppression of HIV-1 replication was observed with CD8 T cells and filtered cell culture supernatants. The soluble factor involved was not a β-chemokine. This resistance to HIV superinfection appears to be mediated at least in part by CD8 T cells that suppress virus production.

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Superinfection with human immunodeficiency virus type 2 can reactivate virus production in baboons but is contained by a CD8 T cell antiviral response

Abstract

Bibliographical note

Funding

UN SDGs

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