Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities

Margey Tadesse; Johan Svenson; Marcel Jaspars; Morten B. Strøm; Mostafa H. Abdelrahman; Jeanette H. Andersen; Espen Hansen; Per E. Kristiansen; Klara Stensvg; Tor Haug

doi:10.1016/j.tetlet.2011.02.027

Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities

Margey Tadesse^* (Corresponding Author), Johan Svenson, Marcel Jaspars, Morten B. Strøm, Mostafa H. Abdelrahman, Jeanette H. Andersen, Espen Hansen, Per E. Kristiansen, Klara Stensvg, Tor Haug

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Synoxazolidinone C is a new member of the synoxazolidinone family of compounds which are dibrominated guanidinium 4-oxazolidinones isolated from the sub-Arctic ascidian Synoicum pulmonaria. The compound was isolated along with synoxazolidinones A and B from the same ascidian extract. Spectroscopic methods revealed that the synoxazolidinone C differed from the other synoxazolidinones by an unprecedented bicyclic partial structure, containing an additional pyrrolidine ring. Synoxazolidinone C exhibited both antibacterial and anticancer activities.

Original language	English
Pages (from-to)	1804-1806
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	15
Early online date	10 Feb 2011
DOIs	https://doi.org/10.1016/j.tetlet.2011.02.027
Publication status	Published - 13 Apr 2011

Keywords

4-Oxazolidinone
Antibacterial
Anticancer
Synoicum pulmonaria
Synoxazolidinone

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title = "Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities",

abstract = "Synoxazolidinone C is a new member of the synoxazolidinone family of compounds which are dibrominated guanidinium 4-oxazolidinones isolated from the sub-Arctic ascidian Synoicum pulmonaria. The compound was isolated along with synoxazolidinones A and B from the same ascidian extract. Spectroscopic methods revealed that the synoxazolidinone C differed from the other synoxazolidinones by an unprecedented bicyclic partial structure, containing an additional pyrrolidine ring. Synoxazolidinone C exhibited both antibacterial and anticancer activities.",

keywords = "4-Oxazolidinone, Antibacterial, Anticancer, Synoicum pulmonaria, Synoxazolidinone",

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doi = "10.1016/j.tetlet.2011.02.027",

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T1 - Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities

AU - Tadesse, Margey

AU - Svenson, Johan

AU - Jaspars, Marcel

AU - Strøm, Morten B.

AU - Abdelrahman, Mostafa H.

AU - Andersen, Jeanette H.

AU - Hansen, Espen

AU - Kristiansen, Per E.

AU - Stensvg, Klara

AU - Haug, Tor

PY - 2011/4/13

Y1 - 2011/4/13

N2 - Synoxazolidinone C is a new member of the synoxazolidinone family of compounds which are dibrominated guanidinium 4-oxazolidinones isolated from the sub-Arctic ascidian Synoicum pulmonaria. The compound was isolated along with synoxazolidinones A and B from the same ascidian extract. Spectroscopic methods revealed that the synoxazolidinone C differed from the other synoxazolidinones by an unprecedented bicyclic partial structure, containing an additional pyrrolidine ring. Synoxazolidinone C exhibited both antibacterial and anticancer activities.

AB - Synoxazolidinone C is a new member of the synoxazolidinone family of compounds which are dibrominated guanidinium 4-oxazolidinones isolated from the sub-Arctic ascidian Synoicum pulmonaria. The compound was isolated along with synoxazolidinones A and B from the same ascidian extract. Spectroscopic methods revealed that the synoxazolidinone C differed from the other synoxazolidinones by an unprecedented bicyclic partial structure, containing an additional pyrrolidine ring. Synoxazolidinone C exhibited both antibacterial and anticancer activities.

KW - 4-Oxazolidinone

KW - Antibacterial

KW - Anticancer

KW - Synoicum pulmonaria

KW - Synoxazolidinone

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DO - 10.1016/j.tetlet.2011.02.027

M3 - Article

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JO - Tetrahedron Letters

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Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities

Abstract

Keywords

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