Takotsubo syndrome: State-of-the-art review by an expert panel – Part 2

Andre Dias, Ivan J. Núñez Gil, Francesco Santoro, John E. Madias, Francesco Pelliccia, Natale Daniele Brunetti, Elena Salmoirago-Blotcher, Scott W. Sharkey, Ingo Eitel, Yoshihiro J. Akashi, Ibrahim El-Battrawy, Emiliana Franco, Ibrahim Akin, Milosz Jaguszewski, Dana Dawson, Vincent M. Figueredo, L. Christian Napp, Thomas Emil Christensen, Kathy Hebert, Itsik Ben-DorYuichi Ozaki, Héctor M. García-Garcia, Alexandre H. Kajita, Takashi Akasaka, Satoshi Kurisu, Amir Lerman, Ron Waksman* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


In part 2 of this two-part manuscript on takotsubo syndrome (TTS), we discuss typical biomarkers (particularly excess catecholamines and what kinds of electrocardiographic information operators should look for) and numerous complications the syndrome can cause. This consensus paper is the result of a multinational effort aiming to summarize the current state of the art on TTS. Several novel and unique sections are emphasized in this document, including the current state of the art on genetics of takotsubo syndrome, microRNAs (miRs), racial differences, role of cardiac spectroscopy and intracoronary imaging, as well as mechanical circulatory support. New structured algorithms are also proposed to aid clinicians in the decision-making process as well as future directions for research given the current lack of evidence-based medical approaches.

Original languageEnglish
Pages (from-to)153-166
Number of pages14
JournalCardiovascular Revascularization Medicine
Issue number2
Early online date17 Nov 2018
Publication statusPublished - Feb 2019

Bibliographical note

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.


  • Catecholamine
  • Heart failure
  • Takotsubo


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