Teleost fish interferons and their role in immunity

Jun Zou, Christopher J. Secombes

Research output: Contribution to journalLiterature reviewpeer-review

316 Citations (Scopus)


Interferons (IFNs) are the hallmark of the vertebrate antiviral system. Two of the three IFN families identified in higher vertebrates are now known to be important for antiviral defence in teleost fish. Based on the cysteine patterns, the fish type I IFN family can be divided into two subfamilies, which possibly interact with distinct receptors for signalling. The fish type II IFN family consists of two members. IFN-gamma with similar functions to mammalian IFN-gamma and a teleost specific IFN-gamma related (IFN-gamma rel) molecule whose functions are not fully elucidated. These two type II IFNs also appear to bind to distinct receptors to exert their functions. It has become clear that fish IFN responses are mediated by the host pattern recognition receptors and an array of transcription factors including the IFN regulatory factors, the Jak/Stat proteins and the suppressor of cytokine signalling (SOCS) molecules. (C) 2011 Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)1376-1387
Number of pages12
JournalDevelopmental and Comparative Immunology
Issue number12
Early online date14 Jul 2011
Publication statusPublished - Dec 2011


  • interferon
  • interferon receptor
  • teleost fish
  • antiviral defence
  • evolution
  • trout oncorhynchus-mykiss
  • salmon salmo-salar
  • zebrafish danio-rerio
  • carassius-auratus L.
  • carp cyprinus-carpio
  • toll-like receptor-3
  • regulatory factor-I
  • double-stranded-RNA
  • NF-kappa-B
  • rainbow-trout


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