Th1/Th2 cytokines in AIDS: sorting out the confusion

D. J. Blackbourn

doi:10.1016/S0923-2494(05)80062-8

Th1/Th2 cytokines in AIDS: sorting out the confusion

D. J. Blackbourn

Medical Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The type I/type 2 cytokine balance concept may help to account, at least in part, for the immunopathogenesis of AIDS. Type 1 cytokines are suggested by Clerici and Shearer (this Forum) to prevent CD4 ÷ cell loss and dysfunction by programmed cell death (PCD) and type 2 cytokines enhance PCD. However, the type 1/type 2 cytokine profile relationship and its involvement in disease progression in HIV-
infected individuals is incompletely understood.

Original language	English
Pages (from-to)	715
Number of pages	1
Journal	Research in Immunology
Volume	145
Issue number	8-9
DOIs	https://doi.org/10.1016/S0923-2494(05)80062-8
Publication status	Published - 1994

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10.1016/S0923-2494(05)80062-8

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title = "Th1/Th2 cytokines in AIDS: sorting out the confusion",

abstract = "The type I/type 2 cytokine balance concept may help to account, at least in part, for the immunopathogenesis of AIDS. Type 1 cytokines are suggested by Clerici and Shearer (this Forum) to prevent CD4 ÷ cell loss and dysfunction by programmed cell death (PCD) and type 2 cytokines enhance PCD. However, the type 1/type 2 cytokine profile relationship and its involvement in disease progression in HIV-infected individuals is incompletely understood.",

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AB - The type I/type 2 cytokine balance concept may help to account, at least in part, for the immunopathogenesis of AIDS. Type 1 cytokines are suggested by Clerici and Shearer (this Forum) to prevent CD4 ÷ cell loss and dysfunction by programmed cell death (PCD) and type 2 cytokines enhance PCD. However, the type 1/type 2 cytokine profile relationship and its involvement in disease progression in HIV-infected individuals is incompletely understood.

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Th1/Th2 cytokines in AIDS: sorting out the confusion

Abstract

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