The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice

Diana Collins; Roger Guy Pertwee; Stephen Nicholas Davies

The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice

Diana Collins
, Roger Guy Pertwee
, Stephen Nicholas Davies

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.

Original language	English
Pages (from-to)	R7-R8
Number of pages	2
Journal	European Journal of Pharmacology
Volume	259
Issue number	3
Publication status	Published - 1994

Keywords

CANNABINOID
LONG-TERM POTENTIATION
HIPPOCAMPUS
cannabinoid
drug of abuse
toxicity
mechanism of action
memeory disorder
rat
animal
NMDA receptor
antagonist
long term
potentiation
electrophysiology
in vitro
synthetic product
hippocampus
brain (vertebrate)
central nervous system
rodentia
mammalia
vertebrata

Cite this

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title = "The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice",

abstract = "Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.",

keywords = "CANNABINOID, LONG-TERM POTENTIATION, HIPPOCAMPUS, cannabinoid, drug of abuse, toxicity, mechanism of action, memeory disorder, rat, animal, NMDA receptor, antagonist, long term, potentiation, electrophysiology, in vitro, synthetic product, hippocampus, brain (vertebrate), central nervous system, rodentia, mammalia, vertebrata",

author = "Diana Collins and Pertwee, \{Roger Guy\} and Davies, \{Stephen Nicholas\}",

year = "1994",

language = "English",

volume = "259",

pages = "R7--R8",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice

AU - Collins, Diana

AU - Pertwee, Roger Guy

AU - Davies, Stephen Nicholas

PY - 1994

Y1 - 1994

N2 - Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.

AB - Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.

KW - CANNABINOID

KW - LONG-TERM POTENTIATION

KW - HIPPOCAMPUS

KW - cannabinoid

KW - drug of abuse

KW - toxicity

KW - mechanism of action

KW - memeory disorder

KW - rat

KW - animal

KW - NMDA receptor

KW - antagonist

KW - long term

KW - potentiation

KW - electrophysiology

KW - in vitro

KW - synthetic product

KW - hippocampus

KW - brain (vertebrate)

KW - central nervous system

KW - rodentia

KW - mammalia

KW - vertebrata

M3 - Comment/debate

SN - 0014-2999

VL - 259

SP - R7-R8

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice

Abstract

Keywords

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