The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles

C A  Maltin; Susan Hay; Margaret Inkster Delday; Gerald Lobley; P J  Reeds

The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles

C A Maltin
, Susan Hay
, Margaret Inkster Delday
, Gerald Lobley
, P J Reeds

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

78 Citations (Web of Science)

Abstract

1. Clenbuterol treatment in innervated and denervated phasic extensor digitorum longus, plantaris and gastrocnemius muscles from rats caused a significant increase in RNA and protein contents in all muscles except denervated extensor digitorum longus. 2. All muscles showed an increase in the fractional rate of protein synthesis (Ks) with clenbuterol, but the temporal response varied. 3. The data suggest that the effect of clenbuterol on protein metabolism in innervated muscles is muscle-type specific, and demonstrate the homology of response for denervated muscles.

Original language	English
Pages (from-to)	965-971
Number of pages	7
Journal	Biochemical Journal
Volume	261
Issue number	3
Publication status	Published - 1 Aug 1989

Cite this

@article{260a30c54a1d4dfe936327549dd9683e,

title = "The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles",

abstract = "1. Clenbuterol treatment in innervated and denervated phasic extensor digitorum longus, plantaris and gastrocnemius muscles from rats caused a significant increase in RNA and protein contents in all muscles except denervated extensor digitorum longus. 2. All muscles showed an increase in the fractional rate of protein synthesis (Ks) with clenbuterol, but the temporal response varied. 3. The data suggest that the effect of clenbuterol on protein metabolism in innervated muscles is muscle-type specific, and demonstrate the homology of response for denervated muscles. ",

author = "Maltin, \{C A\} and Susan Hay and Delday, \{Margaret Inkster\} and Gerald Lobley and Reeds, \{P J\}",

year = "1989",

month = aug,

day = "1",

language = "English",

volume = "261",

pages = "965--971",

journal = "Biochemical Journal",

issn = "0264-6021",

publisher = "Portland Press Ltd.",

number = "3",

}

TY - JOUR

T1 - The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles

AU - Maltin, C A

AU - Hay, Susan

AU - Delday, Margaret Inkster

AU - Lobley, Gerald

AU - Reeds, P J

PY - 1989/8/1

Y1 - 1989/8/1

N2 - 1. Clenbuterol treatment in innervated and denervated phasic extensor digitorum longus, plantaris and gastrocnemius muscles from rats caused a significant increase in RNA and protein contents in all muscles except denervated extensor digitorum longus. 2. All muscles showed an increase in the fractional rate of protein synthesis (Ks) with clenbuterol, but the temporal response varied. 3. The data suggest that the effect of clenbuterol on protein metabolism in innervated muscles is muscle-type specific, and demonstrate the homology of response for denervated muscles.

AB - 1. Clenbuterol treatment in innervated and denervated phasic extensor digitorum longus, plantaris and gastrocnemius muscles from rats caused a significant increase in RNA and protein contents in all muscles except denervated extensor digitorum longus. 2. All muscles showed an increase in the fractional rate of protein synthesis (Ks) with clenbuterol, but the temporal response varied. 3. The data suggest that the effect of clenbuterol on protein metabolism in innervated muscles is muscle-type specific, and demonstrate the homology of response for denervated muscles.

M3 - Article

SN - 0264-6021

VL - 261

SP - 965

EP - 971

JO - Biochemical Journal

JF - Biochemical Journal

IS - 3

ER -

The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles

Abstract

Fingerprint

Cite this