The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran

Sina Gerayli; Zahra Meshkat; Alireza Pasdar; Pegah Mosannen Mozafari; Elham Banihashemi; Mohammad Amin Khajavi; Javid Rasekhi

doi:10.5812/jjm.8(4)2015.16741

The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran

Sina Gerayli, Zahra Meshkat, Alireza Pasdar, Pegah Mosannen Mozafari^*, Elham Banihashemi, Mohammad Amin Khajavi, Javid Rasekhi

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. Objectives: This study aimed to evaluate the relationship between OLP and HCV infection in Mashhad, northeast of Iran. Materials and Methods: Blood samples were taken from 134 OLP patients and 134 healthy controls (without OLP) to screen for anti-HCV by ELISA (third generation) and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. Results: Of the 134 OLP patients only three (2.23%) had HCV infection where both anti-HCV and HCV-RNA were positive. All controls were negative for both anti-HCV and HCV-RNA (P = 0.082). Conclusions: Our investigation illustrated that the prevalence of hepatitis C was higher among OLP patients compared to the control group. These findings are in line with previous results that reported a hepatitis C prevalence of 0.19% among the general population of Mashhad.

Original language	English
Article number	e16741
Journal	Jundishapur Journal of Microbiology
Volume	8
Issue number	4
DOIs	https://doi.org/10.5812/jjm.8(4)2015.16741
Publication status	Published - 1 Apr 2015

Bibliographical note

Acknowledgements
The authors would like to thank all patients who contributed to this investigation.

Footnotes
Authors’ Contributions: Sina Gerayli: designed the study, performed the laboratory tests and prepared the preliminary manuscript. Alireza Pasdar: analyzed the data and revised the manuscript. Elham Banihashemi and Mohammad Amin Khajavi: performed the clinical evaluation of OLP patients and controls, and helped with data collection. Pegah Mosannen Mozafari and Zahra Meshkat: granted the entire study and developed the original idea and the protocol.

Funding/Support: This study was supported by a grant from the Vice Chancellor for Research of Mashhad University of Medical Sciences, Mashhad, Iran (grant no. 910620).

Keywords

Anti-HCV
Epidemiology
HCV-RNA
Hepatitis C
Iran
Lichen planus
Oral
Viral infections

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5812/jjm.8(4)2015.16741

Cite this

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title = "The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran",

abstract = "Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. Objectives: This study aimed to evaluate the relationship between OLP and HCV infection in Mashhad, northeast of Iran. Materials and Methods: Blood samples were taken from 134 OLP patients and 134 healthy controls (without OLP) to screen for anti-HCV by ELISA (third generation) and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. Results: Of the 134 OLP patients only three (2.23%) had HCV infection where both anti-HCV and HCV-RNA were positive. All controls were negative for both anti-HCV and HCV-RNA (P = 0.082). Conclusions: Our investigation illustrated that the prevalence of hepatitis C was higher among OLP patients compared to the control group. These findings are in line with previous results that reported a hepatitis C prevalence of 0.19% among the general population of Mashhad.",

keywords = "Anti-HCV, Epidemiology, HCV-RNA, Hepatitis C, Iran, Lichen planus, Oral, Viral infections",

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note = "Acknowledgements The authors would like to thank all patients who contributed to this investigation. Footnotes Authors{\textquoteright} Contributions: Sina Gerayli: designed the study, performed the laboratory tests and prepared the preliminary manuscript. Alireza Pasdar: analyzed the data and revised the manuscript. Elham Banihashemi and Mohammad Amin Khajavi: performed the clinical evaluation of OLP patients and controls, and helped with data collection. Pegah Mosannen Mozafari and Zahra Meshkat: granted the entire study and developed the original idea and the protocol. Funding/Support: This study was supported by a grant from the Vice Chancellor for Research of Mashhad University of Medical Sciences, Mashhad, Iran (grant no. 910620). ",

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AU - Mozafari, Pegah Mosannen

AU - Banihashemi, Elham

AU - Khajavi, Mohammad Amin

AU - Rasekhi, Javid

N1 - Acknowledgements The authors would like to thank all patients who contributed to this investigation. Footnotes Authors’ Contributions: Sina Gerayli: designed the study, performed the laboratory tests and prepared the preliminary manuscript. Alireza Pasdar: analyzed the data and revised the manuscript. Elham Banihashemi and Mohammad Amin Khajavi: performed the clinical evaluation of OLP patients and controls, and helped with data collection. Pegah Mosannen Mozafari and Zahra Meshkat: granted the entire study and developed the original idea and the protocol. Funding/Support: This study was supported by a grant from the Vice Chancellor for Research of Mashhad University of Medical Sciences, Mashhad, Iran (grant no. 910620).

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N2 - Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. Objectives: This study aimed to evaluate the relationship between OLP and HCV infection in Mashhad, northeast of Iran. Materials and Methods: Blood samples were taken from 134 OLP patients and 134 healthy controls (without OLP) to screen for anti-HCV by ELISA (third generation) and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. Results: Of the 134 OLP patients only three (2.23%) had HCV infection where both anti-HCV and HCV-RNA were positive. All controls were negative for both anti-HCV and HCV-RNA (P = 0.082). Conclusions: Our investigation illustrated that the prevalence of hepatitis C was higher among OLP patients compared to the control group. These findings are in line with previous results that reported a hepatitis C prevalence of 0.19% among the general population of Mashhad.

AB - Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. Objectives: This study aimed to evaluate the relationship between OLP and HCV infection in Mashhad, northeast of Iran. Materials and Methods: Blood samples were taken from 134 OLP patients and 134 healthy controls (without OLP) to screen for anti-HCV by ELISA (third generation) and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. Results: Of the 134 OLP patients only three (2.23%) had HCV infection where both anti-HCV and HCV-RNA were positive. All controls were negative for both anti-HCV and HCV-RNA (P = 0.082). Conclusions: Our investigation illustrated that the prevalence of hepatitis C was higher among OLP patients compared to the control group. These findings are in line with previous results that reported a hepatitis C prevalence of 0.19% among the general population of Mashhad.

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ER -

The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran

Abstract

Bibliographical note

Keywords

UN SDGs

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