The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran

Sina Gerayli, Zahra Meshkat, Alireza Pasdar, Pegah Mosannen Mozafari*, Elham Banihashemi, Mohammad Amin Khajavi, Javid Rasekhi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. Objectives: This study aimed to evaluate the relationship between OLP and HCV infection in Mashhad, northeast of Iran. Materials and Methods: Blood samples were taken from 134 OLP patients and 134 healthy controls (without OLP) to screen for anti-HCV by ELISA (third generation) and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. Results: Of the 134 OLP patients only three (2.23%) had HCV infection where both anti-HCV and HCV-RNA were positive. All controls were negative for both anti-HCV and HCV-RNA (P = 0.082). Conclusions: Our investigation illustrated that the prevalence of hepatitis C was higher among OLP patients compared to the control group. These findings are in line with previous results that reported a hepatitis C prevalence of 0.19% among the general population of Mashhad.

Original languageEnglish
Article numbere16741
JournalJundishapur Journal of Microbiology
Issue number4
Publication statusPublished - 1 Apr 2015

Bibliographical note

The authors would like to thank all patients who contributed to this investigation.

Authors’ Contributions: Sina Gerayli: designed the study, performed the laboratory tests and prepared the preliminary manuscript. Alireza Pasdar: analyzed the data and revised the manuscript. Elham Banihashemi and Mohammad Amin Khajavi: performed the clinical evaluation of OLP patients and controls, and helped with data collection. Pegah Mosannen Mozafari and Zahra Meshkat: granted the entire study and developed the original idea and the protocol.

Funding/Support: This study was supported by a grant from the Vice Chancellor for Research of Mashhad University of Medical Sciences, Mashhad, Iran (grant no. 910620).


  • Anti-HCV
  • Epidemiology
  • Hepatitis C
  • Iran
  • Lichen planus
  • Oral
  • Viral infections


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