The biology of pulmonary aspergillus infections

Adilia Warris*

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Citations (Scopus)


Pulmonary aspergillus infections are mainly caused by Aspergillus fumigatus and can be classified based on clinical syndromes into saphrophytic infections, allergic disease and invasive disease. Invasive pulmonary aspergillosis, occurring in immunocompromised patients, reflects the most serious disease with a high case-fatality rate. Patients with cystic fibrosis and severe asthma might develop allergic bronchopulmonary aspergillosis, while saphrophytic infections are observed in patients with lung cavities mainly due to tuberculosis. Histopathologically, a differentiation can be made into angio-invasive and airway-invasive disease. If the host response is too weak or too strong, Aspergillus species are able to cause disease characterized either by damage from the fungus itself or through an exaggerated inflammatory response of the host, in both situations leading to overt disease associated with specific clinical signs and symptoms. The unraveling of the specific host e Aspergillus interaction has not been performed to a great extent and needs attention to improve the management of those clinical syndromes. (C) 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)S36-S41
Number of pages6
JournalJournal of Infection
Issue numberSupplement 1
Early online date15 Aug 2014
Publication statusPublished - Nov 2014
Event11th Annual meeting in Hot Topics in Infection and Immunity in Children: IIC 2013 - Oxford, United Kingdom
Duration: 26 Jun 201328 Jun 2013


  • Pulmonary aspergillosis
  • Invasive aspergillosis
  • Aspergilloma
  • Allergic bronchopulmonary aspergillosis
  • Aspergillus


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