Abstract
The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern. Though Src64B overexpression induced the formation of specialized haemocytes known as lamellocytes, its hyperactivation had no effect on circulating plasmatocyte concentration. Also, there is evidence of non-autonomous regulation as Src64B activity was observed in non-overexpressing plasmatocytes. Finally, Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 335-339 |
| Number of pages | 5 |
| Journal | Journal of Innate Immunity |
| Volume | 1 |
| Issue number | 4 |
| Early online date | 8 Jan 2009 |
| DOIs | |
| Publication status | Published - Jun 2009 |
Keywords
- innate immunity
- tyrosine kinase
- haemocyte
- Src