The control of histone gene expression

Alexander McRobb Rattray, Berndt Marino Muller

Research output: Contribution to journalLiterature reviewpeer-review

45 Citations (Scopus)


Histone proteins are essential for the packaging of DNA into chromosomes. Histone gene expression is cell-cycle-regulated and coupled to DNA replication. Control of histone gene expression occurs at the transcriptional and post-transcriptional level and ensures that a fine balance between histone abundance and DNA replication is maintained for the correct packaging of newly replicated DNA into chromosomes. In the present paper, we review histone gene expression, highlighting the control mechanisms and key molecules involved in this process.
Original languageEnglish
Pages (from-to)880-885
Number of pages6
JournalBiochemical Society Transactions
Issue number4
Publication statusPublished - Aug 2012


  • cell cycle
  • DNA replication
  • histone gene expression
  • RNA degradation
  • RNA processing
  • translation


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