The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed; Fatemeh Varse; Hamid Reza Baradaran; Yousef Moradi; Sorour Khateri; Emilie Friberg; Zaher Khazaei; Saeedeh Gharahjeh; Shahrzad Tehrani; Amir-Babak Sioofy-Khojine; Zahra Najmi

doi:10.1186/s12885-019-5748-4

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed
, Fatemeh Varse
, Hamid Reza Baradaran
, Yousef Moradi (Corresponding Author)
, Sorour Khateri
, Emilie Friberg
, Zaher Khazaei
, Saeedeh Gharahjeh
, Shahrzad Tehrani
, Amir-Babak Sioofy-Khojine
, Zahra Najmi

Applied Health Sciences

Iran University of Medical Sciences
Kurdistan University of Medical Sciences
Karolinska Institutet
Sabzevar University of Medical Sciences
Tehran University of Medical Sciences
Qom University of Medical Sciences
Tampere University
Zanjan University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.

METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.

RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).

CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

Original language	English
Article number	527
Number of pages	10
Journal	BMC Cancer
Volume	19
DOIs	https://doi.org/10.1186/s12885-019-5748-4
Publication status	Published - 31 May 2019

Bibliographical note

Funding
This research was funded by Systematic Review Network Center, Iran University of Medical Sciences (Grant Number 97–4–37-13922).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diabetes
endometrial cancer
meta-analysis
Risk
Endometrial Cancer
Meta-analysis

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10.1186/s12885-019-5748-4Licence: CC BY

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis
© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 1.37 MBLicence: CC BY

Cite this

@article{daf0950f520f42d5a2f19f618fbd34b8,

title = "The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis",

abstract = "BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95\% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95\% CI 1.21-2.01), and it was 1.85 (95\% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95\% CI 1.34-1.97).CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.",

keywords = "Diabetes, endometrial cancer, meta-analysis, Risk, Endometrial Cancer, Meta-analysis",

author = "Lotfolah Saed and Fatemeh Varse and Baradaran, \{Hamid Reza\} and Yousef Moradi and Sorour Khateri and Emilie Friberg and Zaher Khazaei and Saeedeh Gharahjeh and Shahrzad Tehrani and Amir-Babak Sioofy-Khojine and Zahra Najmi",

note = "Funding This research was funded by Systematic Review Network Center, Iran University of Medical Sciences (Grant Number 97{\textendash}4{\textendash}37-13922).",

year = "2019",

month = may,

day = "31",

doi = "10.1186/s12885-019-5748-4",

language = "English",

volume = "19",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central",

}

TY - JOUR

T1 - The effect of diabetes on the risk of endometrial Cancer

T2 - an updated a systematic review and meta-analysis

AU - Saed, Lotfolah

AU - Varse, Fatemeh

AU - Baradaran, Hamid Reza

AU - Moradi, Yousef

AU - Khateri, Sorour

AU - Friberg, Emilie

AU - Khazaei, Zaher

AU - Gharahjeh, Saeedeh

AU - Tehrani, Shahrzad

AU - Sioofy-Khojine, Amir-Babak

AU - Najmi, Zahra

N1 - Funding This research was funded by Systematic Review Network Center, Iran University of Medical Sciences (Grant Number 97–4–37-13922).

PY - 2019/5/31

Y1 - 2019/5/31

N2 - BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

AB - BACKGROUND: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence.METHODS: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis.RESULTS: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95% CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95% CI 1.21-2.01), and it was 1.85 (95% CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95% CI 1.34-1.97).CONCLUSIONS: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes.

KW - Diabetes

KW - endometrial cancer

KW - meta-analysis

KW - Risk

KW - Endometrial Cancer

KW - Meta-analysis

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UR - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5748-4

UR - http://www.mendeley.com/research/effect-diabetes-risk-endometrial-cancer-updated-systematic-review-metaanalysis

U2 - 10.1186/s12885-019-5748-4

DO - 10.1186/s12885-019-5748-4

M3 - Article

C2 - 31151429

SN - 1471-2407

VL - 19

JO - BMC Cancer

JF - BMC Cancer

M1 - 527

ER -

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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