The immuno-inflammatory cascade

H. F. Galley, N. R. Webster*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)


Severe sepsis complicated by multi-organ dysfunction syndrome (MODS) is a major cause of death in intensive care units, with a mortality rate in excess of 50 %. The outcome is determined not only by the infection but also by the intensity of the immunoinflammatory response. This response is essential for the resolution of infection but may occur in an uncontrolled manner causing damage to the host. The pronounced synergy and interaction of the components of the immune system dictate that modulation may result in either immunostimulation or immunosuppression. Coordination of the host immune response to infection and inflammation in terms of expression of the effector molecules is vital to an optimum response
Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalBritish Journal of Anaesthesia
Issue number1
Publication statusPublished - 1 Jan 1996


  • Complications, infections
  • Immune response
  • Proteins, cytokines


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