The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK

Andrew Lloyd; David Brendan Price; Ruth Brown

doi:10.3132/pcrj.2007.00002

The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK

Andrew Lloyd, David Brendan Price, Ruth Brown

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

INTRODUCTION: The objective of this study was to report the impact of exacerbations on health-related quality of life (HRQL) and health utility in patients with moderate to severe asthma (BTS levels 4 & 5) in the UK.

MATERIALS AND METHODS: Prospective data regarding HRQL were collected (n=112) using the EQ-5D, mini Asthma Quality of Life Questionnaire (mAQLQ), and Asthma Symptom Utility (ASUI) measures.

RESULTS: The mAQLQ, EQ-5D and ASUI were all significantly worse for patients suffering exacerbations (p<0.001) compared to those without. There was also evidence of a further HRQL decrement in those patients who had been admitted to hospital as a result of an exacerbation during the four-week study.

CONCLUSIONS: This study documents the impact of asthma exacerbations on HRQL in patients with moderate to severe asthma. There was some evidence of floor effects on the mAQLQ and ASUI in their ability to capture the impact of exacerbations. These study data are suitable for use in economic evaluations.

Original language	English
Pages (from-to)	22-27
Number of pages	6
Journal	Primary Care Respiratory Journal
Volume	16
Issue number	1
DOIs	https://doi.org/10.3132/pcrj.2007.00002
Publication status	Published - Feb 2007

Keywords

asthma
asthma exacerbations
quality of life
utility

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title = "The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK",

abstract = "INTRODUCTION: The objective of this study was to report the impact of exacerbations on health-related quality of life (HRQL) and health utility in patients with moderate to severe asthma (BTS levels 4 & 5) in the UK. MATERIALS AND METHODS: Prospective data regarding HRQL were collected (n=112) using the EQ-5D, mini Asthma Quality of Life Questionnaire (mAQLQ), and Asthma Symptom Utility (ASUI) measures. RESULTS: The mAQLQ, EQ-5D and ASUI were all significantly worse for patients suffering exacerbations (p<0.001) compared to those without. There was also evidence of a further HRQL decrement in those patients who had been admitted to hospital as a result of an exacerbation during the four-week study. CONCLUSIONS: This study documents the impact of asthma exacerbations on HRQL in patients with moderate to severe asthma. There was some evidence of floor effects on the mAQLQ and ASUI in their ability to capture the impact of exacerbations. These study data are suitable for use in economic evaluations.",

keywords = "asthma, asthma exacerbations, quality of life, utility",

author = "Andrew Lloyd and Price, {David Brendan} and Ruth Brown",

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doi = "10.3132/pcrj.2007.00002",

language = "English",

volume = "16",

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journal = "Primary Care Respiratory Journal",

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T1 - The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK

AU - Lloyd, Andrew

AU - Price, David Brendan

AU - Brown, Ruth

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N2 - INTRODUCTION: The objective of this study was to report the impact of exacerbations on health-related quality of life (HRQL) and health utility in patients with moderate to severe asthma (BTS levels 4 & 5) in the UK. MATERIALS AND METHODS: Prospective data regarding HRQL were collected (n=112) using the EQ-5D, mini Asthma Quality of Life Questionnaire (mAQLQ), and Asthma Symptom Utility (ASUI) measures. RESULTS: The mAQLQ, EQ-5D and ASUI were all significantly worse for patients suffering exacerbations (p<0.001) compared to those without. There was also evidence of a further HRQL decrement in those patients who had been admitted to hospital as a result of an exacerbation during the four-week study. CONCLUSIONS: This study documents the impact of asthma exacerbations on HRQL in patients with moderate to severe asthma. There was some evidence of floor effects on the mAQLQ and ASUI in their ability to capture the impact of exacerbations. These study data are suitable for use in economic evaluations.

AB - INTRODUCTION: The objective of this study was to report the impact of exacerbations on health-related quality of life (HRQL) and health utility in patients with moderate to severe asthma (BTS levels 4 & 5) in the UK. MATERIALS AND METHODS: Prospective data regarding HRQL were collected (n=112) using the EQ-5D, mini Asthma Quality of Life Questionnaire (mAQLQ), and Asthma Symptom Utility (ASUI) measures. RESULTS: The mAQLQ, EQ-5D and ASUI were all significantly worse for patients suffering exacerbations (p<0.001) compared to those without. There was also evidence of a further HRQL decrement in those patients who had been admitted to hospital as a result of an exacerbation during the four-week study. CONCLUSIONS: This study documents the impact of asthma exacerbations on HRQL in patients with moderate to severe asthma. There was some evidence of floor effects on the mAQLQ and ASUI in their ability to capture the impact of exacerbations. These study data are suitable for use in economic evaluations.

KW - asthma

KW - asthma exacerbations

KW - quality of life

KW - utility

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DO - 10.3132/pcrj.2007.00002

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VL - 16

SP - 22

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JO - Primary Care Respiratory Journal

JF - Primary Care Respiratory Journal

IS - 1

ER -

The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK

Abstract

Keywords

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