Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.
|Number of pages||10|
|Journal||Journal of Clinical and Experimental Neuropsychology|
|Early online date||8 Jan 2016|
|Publication status||Published - 2016|
We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington’s Disease Society of America, and the Huntington Study Group.
This work was supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke [grant number 5R01NS040068] awarded to Jane Paulsen; CHDI Foundation, Inc. [grant number A6266], [grant number A2015] awarded to Jane Paulsen; and Cognitive and Functional Brain Changes in Preclinical Huntington’s Disease (HD) [grant number R01NS054893] awarded to Jane Paulsen.
- Huntington disease
- oculomotor functioning
- processing speed