The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho; Jeffrey D. Long; Holly J. Westervelt; Megan M. Smith; Jared M. Bruce; Ji-In Kim; James A. Mills; Jane S. Paulsen; PREDICT-HD Investigators And Coordinators Of The Huntington Study Group

doi:10.1080/13803395.2015.1101054

The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho, Jeffrey D. Long, Holly J. Westervelt, Megan M. Smith, Jared M. Bruce, Ji-In Kim, James A. Mills, Jane S. Paulsen (Corresponding Author), PREDICT-HD Investigators And Coordinators Of The Huntington Study Group

Medical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

Original language	English
Pages (from-to)	217-226
Number of pages	10
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	38
Issue number	2
Early online date	8 Jan 2016
DOIs	https://doi.org/10.1080/13803395.2015.1101054
Publication status	Published - 2016

Bibliographical note

Acknowledgements
We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington’s Disease Society of America, and the Huntington Study Group.

Funding
This work was supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke [grant number 5R01NS040068] awarded to Jane Paulsen; CHDI Foundation, Inc. [grant number A6266], [grant number A2015] awarded to Jane Paulsen; and Cognitive and Functional Brain Changes in Preclinical Huntington’s Disease (HD) [grant number R01NS054893] awarded to Jane Paulsen.

Keywords

Huntington disease
PREDICT-HD
oculomotor functioning
neuropsychology
processing speed

Access to Document

10.1080/13803395.2015.1101054Licence: Unspecified

Cite this

Carvalho, J. O., Long, J. D., Westervelt, H. J., Smith, M. M., Bruce, J. M., Kim, J-I., Mills, J. A., Paulsen, J. S., & PREDICT-HD Investigators And Coordinators Of The Huntington Study Group (2016). The impact of oculomotor functioning on neuropsychological performance in Huntington disease. Journal of Clinical and Experimental Neuropsychology, 38(2), 217-226. https://doi.org/10.1080/13803395.2015.1101054

Carvalho, JO, Long, JD, Westervelt, HJ, Smith, MM, Bruce, JM, Kim, J-I, Mills, JA, Paulsen, JS & PREDICT-HD Investigators And Coordinators Of The Huntington Study Group 2016, 'The impact of oculomotor functioning on neuropsychological performance in Huntington disease', Journal of Clinical and Experimental Neuropsychology, vol. 38, no. 2, pp. 217-226. https://doi.org/10.1080/13803395.2015.1101054

@article{3b43760548774dd386d0b02d37e08b32,

title = "The impact of oculomotor functioning on neuropsychological performance in Huntington disease",

abstract = "Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.",

keywords = "Huntington disease, PREDICT-HD, oculomotor functioning, neuropsychology, processing speed",

author = "Carvalho, {Janessa O.} and Long, {Jeffrey D.} and Westervelt, {Holly J.} and Smith, {Megan M.} and Bruce, {Jared M.} and Ji-In Kim and Mills, {James A.} and Paulsen, {Jane S.} and {PREDICT-HD Investigators And Coordinators Of The Huntington Study Group}",

note = "Acknowledgements We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington{\textquoteright}s Disease Society of America, and the Huntington Study Group. Funding This work was supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke [grant number 5R01NS040068] awarded to Jane Paulsen; CHDI Foundation, Inc. [grant number A6266], [grant number A2015] awarded to Jane Paulsen; and Cognitive and Functional Brain Changes in Preclinical Huntington{\textquoteright}s Disease (HD) [grant number R01NS054893] awarded to Jane Paulsen.",

year = "2016",

doi = "10.1080/13803395.2015.1101054",

language = "English",

volume = "38",

pages = "217--226",

journal = "Journal of Clinical and Experimental Neuropsychology",

issn = "0168-8634",

publisher = "Psychology Press Ltd",

number = "2",

}

TY - JOUR

T1 - The impact of oculomotor functioning on neuropsychological performance in Huntington disease

AU - Carvalho, Janessa O.

AU - Long, Jeffrey D.

AU - Westervelt, Holly J.

AU - Smith, Megan M.

AU - Bruce, Jared M.

AU - Kim, Ji-In

AU - Mills, James A.

AU - Paulsen, Jane S.

AU - PREDICT-HD Investigators And Coordinators Of The Huntington Study Group

N1 - Acknowledgements We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington’s Disease Society of America, and the Huntington Study Group. Funding This work was supported by the National Institutes for Health, National Institute of Neurological Disorders and Stroke [grant number 5R01NS040068] awarded to Jane Paulsen; CHDI Foundation, Inc. [grant number A6266], [grant number A2015] awarded to Jane Paulsen; and Cognitive and Functional Brain Changes in Preclinical Huntington’s Disease (HD) [grant number R01NS054893] awarded to Jane Paulsen.

PY - 2016

Y1 - 2016

N2 - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

AB - Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

KW - Huntington disease

KW - PREDICT-HD

KW - oculomotor functioning

KW - neuropsychology

KW - processing speed

U2 - 10.1080/13803395.2015.1101054

DO - 10.1080/13803395.2015.1101054

M3 - Article

C2 - 26745770

SN - 0168-8634

VL - 38

SP - 217

EP - 226

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

IS - 2

ER -

The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this