The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

L. V. Burgin; L. Edelsten; R. M. Aspden

doi:10.1016/j.medengphy.2013.11.002

The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

L. V. Burgin
, L. Edelsten
, R. M. Aspden^*

^*Corresponding author for this work

University of Aberdeen

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

15 Downloads (Pure)

Abstract

The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5 rnJ and velocity 1.25 m s(-1). The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves.

Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150 MPa. These values compared with 1-3 MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25% of the variance in modulus. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	226-232
Number of pages	7
Journal	Medical Engineering & Physics
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.medengphy.2013.11.002
Publication status	Published - Feb 2014

Bibliographical note

Funding

This study was funded by a project grant from Arthritis Research UK (formerly the Arthritis Research Campaign) Grant number A0542 that provided a salary for LVB. The funder had no involvement in the design or execution of the study or the publication of results.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

articular cartilage
human
femoral head
impact
mechanical properties
composition
material properties
femoral-head cartilage
chondrocyte viability
in-vitro
compressive modulus
connective tissues
water-loss
lower-limb
bone
stiffness
collagen

Access to Document

10.1016/j.medengphy.2013.11.002

Med Engng Phys human cartilage impact
NOTICE: this is the author’s version of a work that was accepted for publication in Medical Engineering and Physics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in MEDICAL ENGINEERING AND PHYSICS, VOL 36, ISSUE 2, (2014) DOI: 10.1016/j.medengphy.2013.11.002
Accepted author manuscript, 168 KB

Cite this

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title = "The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading",

abstract = "The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5 rnJ and velocity 1.25 m s(-1). The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves.Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150 MPa. These values compared with 1-3 MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25\% of the variance in modulus. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.",

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N2 - The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5 rnJ and velocity 1.25 m s(-1). The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves.Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150 MPa. These values compared with 1-3 MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25% of the variance in modulus. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

AB - The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5 rnJ and velocity 1.25 m s(-1). The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves.Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150 MPa. These values compared with 1-3 MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25% of the variance in modulus. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.

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KW - composition

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The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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