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Bibliographical noteFunding Information:
Our work is currently supported by grants from The Association for International Cancer Research (DJB: ref. 01-242) and Cancer Research UK (OBS and DJB: ref. C7934). OBS is also supported through a career development grant provided by the Wellcome Trust. We thank G.K. Paterson (University of Glasgow) and Dr. Claire Harris (University of Wales College of Medicine) for critical reading of the manuscript. We regret that the citation of many elegant studies contributing to this field and to the present review was omitted due to space constraints.