The Role of redo-Sentinel Lymph Node Biopsy in Patients With Prior Ipsilateral Breast Cancer Surgery

Margo Rose F. Macnab, Gabrielle Slater, Mairi Fuller, Beatrix Elsberger, Lesley Lovell, Roger T. Staff, Yazan A. Masannat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review



Sentinel Lymph Node Biopsy (SLNB) is used to stage the axilla, but there is limited data in patients with prior ipsilateral breast cancer. This study compares redo-SLNB (reSLNB) and Axillary node sample (ANS) in this sub-cohort of patients.

Materials and Methods

This is a retrospective study looking at patients with a new ipsilateral primary or recurrence with history of breast-conserving surgery. Planned and performed surgery, patient demographics and previous treatments were recorded. Node positivity and success rate of reSLNB was analyzed.


A total of 86 patients were identified that had mastectomy for ipsilateral recurrent disease with radiologically negative axilla. Out of the 48 that had reSLNB, 35(72.9%) were successful. Nineteen percent of the reSLNB had positive axillae and 20% of the ANS patients. reSLNB success rate was significantly lower amongst patients with previous axillary surgery (P = .014) and previous positive nodes(P = .001).


reSLNB should be considered to restage the axilla in patients with previous history of ipsilateral cancer especially that there is growing evidence showing good identification rate.

Original languageEnglish
Pages (from-to)e674-e679
Number of pages6
JournalClinical Breast Cancer
Issue number5
Early online date17 Jun 2022
Publication statusPublished - Jul 2022

Bibliographical note

There is no funding for this project as this is a retrospective review of our practice. This project did not get any grants or funding in the public, commercial or a none profit sector. Open Access via Elsevier agreement.

Data Availability Statement

The data collected was anonymized and analyzed and the data analyzed is included in the tables. We don't have the permission to publicly share the data from the Caldicott Guardian application through the local governance department, but the data will be kept for few years after publication with the corresponding Author (YM) and any further enquiries can be directed to him.


  • Axillary node sample
  • Axillary Surgery
  • Breast cancer recurrence
  • Breast surgery
  • Sentinel node biopsy


Dive into the research topics of 'The Role of redo-Sentinel Lymph Node Biopsy in Patients With Prior Ipsilateral Breast Cancer Surgery'. Together they form a unique fingerprint.

Cite this