Abstract
Reaction of carbodiimides with alpha-Br(Cl)-aryl acetic acids produces N,N'-substituted 5-arylhydantoins under very mild conditions and high yields. When the carbodiimides are generated in situ by Staudinger reaction, the process becomes a one-pot, three-component sequential synthesis of libraries of differently substituted 5-arylhydantoins.
| Original language | English |
|---|---|
| Pages (from-to) | 3016-3020 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 1 Dec 2008 |
| Externally published | Yes |
Keywords
- heterocycles
- multicomponent reactions
- combinatorial chemistry
- carbodiimides
- sequential synthesis
- organic-synthesis
- substituted hydantoins
- tandem
- chemistry
- cycloadditions
- methodology
- acids