To Sense or Die: Mechanisms of Temperature Sensing in Fungal Pathogens

Michelle D. Leach; Leah E. Cowen

doi:10.1007/s12281-014-0182-1

To Sense or Die: Mechanisms of Temperature Sensing in Fungal Pathogens

Michelle D. Leach
, Leah E. Cowen^*

^*Corresponding author for this work

Medical Sciences

University of Toronto

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Temperature is a ubiquitous environmental variable that can profoundly influence the physiology of living cells as it changes over time and space. All organisms have devised sophisticated mechanisms to sense and respond to changing temperature. Complex mammals, elegant worms, or pathogens struggling for survival in their host, each have systems allowing them to persist and thrive in the face of thermal fluctuation. The ability to grow at 37 °C is essential for virulence in a mammalian host, with further increases in temperature in the form of fever being a prevalent response to pathogen invasion. An understanding of how pathogens sense temperature is imperative for appreciating mechanisms of virulence. This review will dissect the mechanisms fungal pathogens use to sense temperature.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	Current Fungal Infection Reports
Volume	8
Issue number	2
Early online date	23 Mar 2014
DOIs	https://doi.org/10.1007/s12281-014-0182-1
Publication status	Published - Jun 2014

Bibliographical note

Acknowledgments
MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), and LEC is supported by a Canada Research Chair in Microbial Genomics and Infectious Disease, by a Ministry of Research and Innovation Early Researcher Award, by Natural Sciences & Engineering Research Council Discovery Grant # 355965, and by Canadian Institutes of Health Research Grants MOP-86452 and MOP-119520.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Candida albicans
Fatty acids
Fungal pathogenicity
Heat shock
RNA thermometers
Thermal adaptation
Unfolded proteins

Access to Document

10.1007/s12281-014-0182-1Licence: Unspecified

Cite this

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title = "To Sense or Die: Mechanisms of Temperature Sensing in Fungal Pathogens",

abstract = "Temperature is a ubiquitous environmental variable that can profoundly influence the physiology of living cells as it changes over time and space. All organisms have devised sophisticated mechanisms to sense and respond to changing temperature. Complex mammals, elegant worms, or pathogens struggling for survival in their host, each have systems allowing them to persist and thrive in the face of thermal fluctuation. The ability to grow at 37 °C is essential for virulence in a mammalian host, with further increases in temperature in the form of fever being a prevalent response to pathogen invasion. An understanding of how pathogens sense temperature is imperative for appreciating mechanisms of virulence. This review will dissect the mechanisms fungal pathogens use to sense temperature.",

keywords = "Candida albicans, Fatty acids, Fungal pathogenicity, Heat shock, RNA thermometers, Thermal adaptation, Unfolded proteins",

author = "Leach, \{Michelle D.\} and Cowen, \{Leah E.\}",

note = "Acknowledgments MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), and LEC is supported by a Canada Research Chair in Microbial Genomics and Infectious Disease, by a Ministry of Research and Innovation Early Researcher Award, by Natural Sciences \& Engineering Research Council Discovery Grant \# 355965, and by Canadian Institutes of Health Research Grants MOP-86452 and MOP-119520.",

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doi = "10.1007/s12281-014-0182-1",

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N2 - Temperature is a ubiquitous environmental variable that can profoundly influence the physiology of living cells as it changes over time and space. All organisms have devised sophisticated mechanisms to sense and respond to changing temperature. Complex mammals, elegant worms, or pathogens struggling for survival in their host, each have systems allowing them to persist and thrive in the face of thermal fluctuation. The ability to grow at 37 °C is essential for virulence in a mammalian host, with further increases in temperature in the form of fever being a prevalent response to pathogen invasion. An understanding of how pathogens sense temperature is imperative for appreciating mechanisms of virulence. This review will dissect the mechanisms fungal pathogens use to sense temperature.

AB - Temperature is a ubiquitous environmental variable that can profoundly influence the physiology of living cells as it changes over time and space. All organisms have devised sophisticated mechanisms to sense and respond to changing temperature. Complex mammals, elegant worms, or pathogens struggling for survival in their host, each have systems allowing them to persist and thrive in the face of thermal fluctuation. The ability to grow at 37 °C is essential for virulence in a mammalian host, with further increases in temperature in the form of fever being a prevalent response to pathogen invasion. An understanding of how pathogens sense temperature is imperative for appreciating mechanisms of virulence. This review will dissect the mechanisms fungal pathogens use to sense temperature.

KW - Candida albicans

KW - Fatty acids

KW - Fungal pathogenicity

KW - Heat shock

KW - RNA thermometers

KW - Thermal adaptation

KW - Unfolded proteins

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To Sense or Die: Mechanisms of Temperature Sensing in Fungal Pathogens

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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