Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Elzbieta Masiewicz, George Ashcroft, David Boddie, Sinclair R Dundas, Danuta Kruk, Lionel Broche* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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This work explores what Fast Field-Cycling Nuclear Magnetic Resonance (FFC-NMR) relaxometry brings for the study of sarcoma to guide future in vivo analyses of patients. We present the results of an ex vivo pilot study involving 10 cases of biopsy-proven sarcoma and we propose a quantitative method to analyse 1H NMR relaxation dispersion profiles based on a model-free approach describing the main dynamical processes in the tissues and assessing the amplitude of the Quadrupole Relaxation Enhancement effects due to 14N. This approach showed five distinct groups of dispersion profiles indicating five discrete categories of sarcoma, with differences attributable to microstructure and rigidity. Data from tissues surrounding sarcomas indicated very significant variations with the proximity to tumour, which may be attributed to varying water content but also to tissue remodelling processes due to the sarcoma. This pilot study illustrates the potential of FFC relaxometry for the detection and characterisation of sarcoma.

Original languageEnglish
Article number14207
Number of pages11
JournalScientific Reports
Publication statusPublished - 26 Aug 2020

Bibliographical note

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”). This work received support from the EURELAX COST Action CA15209, supported by COST (European Cooperation in Science and Technology). The authors would like to thank Professor David Lurie for his continuous support.


  • biological physics
  • biomarkers
  • biophysical methods
  • bone cancer
  • characterization and analytical techniques
  • molecular biophysics
  • sarcoma
  • structure of solids and liquids


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