Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies

Ceyda Icsel; Veysel T. Yilmaz; Ferda Ari; Engin Ulukaya; William T. A. Harrison

doi:10.1016/j.ejmech.2012.12.002

Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies

Ceyda Icsel
, Veysel T. Yilmaz^*
, Ferda Ari
, Engin Ulukaya
, William T. A. Harrison

^*Corresponding author for this work

Chemistry

Uludag University

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Four trans-palladium(II)- and trans-platinum(II)-chlorido complexes, trans-[PdCl₂(2-hmpy)₂] (1), trans-[PtCl ₂(2-hmpy)₂] (2), trans-[PdCl₂(2-hepy) ₂] (3) and trans-[PtCl₂(2-hepy)₂] (4) (2-hmpy = 2-(hydroxymethyl)pyridine and 2-hepy = 2-(2-hydroxyethyl)pyridine), have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray diffraction. The binding properties of these complexes with fish sperm DNA (FS-DNA) were investigated by UV titration, viscosity, thermal denaturation and electrophoresis measurements. The complexes can bind to FS-DNA and complex 4 exhibits the highest binding constant. Gel electrophoresis assay demonstrates that all the complexes can cleave the pCMV-βgal plasmid DNA to a different degree. The cytotoxic activities of the complexes were tested against four different cancer cell lines. In general, the platinum(II) complexes are more effective than the isostructural palladium(II) complexes. Complex 4 shows high anticancer activity, compared to transplatin, cisplatin, carboplatin and oxaliplatin.

Original language	English
Pages (from-to)	386-394
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	60
Early online date	8 Dec 2012
DOIs	https://doi.org/10.1016/j.ejmech.2012.12.002
Publication status	Published - Feb 2013

Bibliographical note

Acknowledgments
This work is a part of a research project 111T099. We thank TUBITAK for the financial support given to the project.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

2-(2-Hydroxyethyl) pyridine
2-(Hydroxymethyl)pyridine
Cytotoxic activity
DNA binding
Transplatinum complexes

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Icsel, C., Yilmaz, V. T., Ari, F., Ulukaya, E., & Harrison, W. T. A. (2013). Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies. European Journal of Medicinal Chemistry, 60, 386-394. https://doi.org/10.1016/j.ejmech.2012.12.002

Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies. / Icsel, Ceyda; Yilmaz, Veysel T.; Ari, Ferda et al.
In: European Journal of Medicinal Chemistry, Vol. 60, 02.2013, p. 386-394.

Research output: Contribution to journal › Article › peer-review

Icsel, C, Yilmaz, VT, Ari, F, Ulukaya, E & Harrison, WTA 2013, 'Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies', European Journal of Medicinal Chemistry, vol. 60, pp. 386-394. https://doi.org/10.1016/j.ejmech.2012.12.002

Icsel C, Yilmaz VT, Ari F, Ulukaya E, Harrison WTA. Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies. European Journal of Medicinal Chemistry. 2013 Feb;60:386-394. Epub 2012 Dec 8. doi: 10.1016/j.ejmech.2012.12.002

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abstract = "Four trans-palladium(II)- and trans-platinum(II)-chlorido complexes, trans-[PdCl2(2-hmpy)2] (1), trans-[PtCl 2(2-hmpy)2] (2), trans-[PdCl2(2-hepy) 2] (3) and trans-[PtCl2(2-hepy)2] (4) (2-hmpy = 2-(hydroxymethyl)pyridine and 2-hepy = 2-(2-hydroxyethyl)pyridine), have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray diffraction. The binding properties of these complexes with fish sperm DNA (FS-DNA) were investigated by UV titration, viscosity, thermal denaturation and electrophoresis measurements. The complexes can bind to FS-DNA and complex 4 exhibits the highest binding constant. Gel electrophoresis assay demonstrates that all the complexes can cleave the pCMV-βgal plasmid DNA to a different degree. The cytotoxic activities of the complexes were tested against four different cancer cell lines. In general, the platinum(II) complexes are more effective than the isostructural palladium(II) complexes. Complex 4 shows high anticancer activity, compared to transplatin, cisplatin, carboplatin and oxaliplatin.",

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author = "Ceyda Icsel and Yilmaz, \{Veysel T.\} and Ferda Ari and Engin Ulukaya and Harrison, \{William T. A.\}",

note = "Acknowledgments This work is a part of a research project 111T099. We thank TUBITAK for the financial support given to the project.",

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AU - Icsel, Ceyda

AU - Yilmaz, Veysel T.

AU - Ari, Ferda

AU - Ulukaya, Engin

AU - Harrison, William T. A.

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AB - Four trans-palladium(II)- and trans-platinum(II)-chlorido complexes, trans-[PdCl2(2-hmpy)2] (1), trans-[PtCl 2(2-hmpy)2] (2), trans-[PdCl2(2-hepy) 2] (3) and trans-[PtCl2(2-hepy)2] (4) (2-hmpy = 2-(hydroxymethyl)pyridine and 2-hepy = 2-(2-hydroxyethyl)pyridine), have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray diffraction. The binding properties of these complexes with fish sperm DNA (FS-DNA) were investigated by UV titration, viscosity, thermal denaturation and electrophoresis measurements. The complexes can bind to FS-DNA and complex 4 exhibits the highest binding constant. Gel electrophoresis assay demonstrates that all the complexes can cleave the pCMV-βgal plasmid DNA to a different degree. The cytotoxic activities of the complexes were tested against four different cancer cell lines. In general, the platinum(II) complexes are more effective than the isostructural palladium(II) complexes. Complex 4 shows high anticancer activity, compared to transplatin, cisplatin, carboplatin and oxaliplatin.

KW - 2-(2-Hydroxyethyl) pyridine

KW - 2-(Hydroxymethyl)pyridine

KW - Cytotoxic activity

KW - DNA binding

KW - Transplatinum complexes

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ER -

Trans-Dichloridopalladium(II) and platinum(II) complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine: Synthesis, structural characterization, DNA binding and in vitro cytotoxicity studies

Abstract

Bibliographical note

UN SDGs

Keywords

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