TY - JOUR
T1 - Transient virus infection and pathogenesis of a new HIV type 2 isolate, UC12, in baboons
AU - Locher, Christopher P.
AU - Blackbourn, David J.
AU - Herndier, Brian G.
AU - Reyes-Terán, Gustavo
AU - Barnett, Susan W.
AU - Murthy, Krishna K.
AU - Levy, Jay A.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - We have previously shown that baboons (Papio cynocephalus) can be persistently infected with HIV-2 and some baboons progress to an AIDS-like disease with a CD4+ T cell decline, cachexia, alopecia, and Kaposi's sarcoma-like fibromatosis. In this study, we found that a new virus isolate, HIV-2(UC12), replicated to high levels in baboon peripheral blood mononuclear cells (PBMCs) in vitro. Three baboons were subsequently inoculated and had plasma viral RNA loads that peaked between 15,000 and 7000 copies/ml at 2 weeks postinfection. Virus was isolated from the PBMCs for up to 6 months. Although PBMCs were subsequently virus culture negative, virus could be recovered from the spleen, lymph nodes, and tonsils, indicating that HIV-2 was sequestered within these lymphoid tissues. HIV-2-associated pathology included follicular lysis, vascular proliferation, and lymphoid depletion. This study indicated that HIV-2(UC12) infection in baboons can cause HIV- associated pathological abnormalities within the lymphatic tissues and that the high level of HIV-2(UC12) replication in vitro was not predictive of replication in vivo.
AB - We have previously shown that baboons (Papio cynocephalus) can be persistently infected with HIV-2 and some baboons progress to an AIDS-like disease with a CD4+ T cell decline, cachexia, alopecia, and Kaposi's sarcoma-like fibromatosis. In this study, we found that a new virus isolate, HIV-2(UC12), replicated to high levels in baboon peripheral blood mononuclear cells (PBMCs) in vitro. Three baboons were subsequently inoculated and had plasma viral RNA loads that peaked between 15,000 and 7000 copies/ml at 2 weeks postinfection. Virus was isolated from the PBMCs for up to 6 months. Although PBMCs were subsequently virus culture negative, virus could be recovered from the spleen, lymph nodes, and tonsils, indicating that HIV-2 was sequestered within these lymphoid tissues. HIV-2-associated pathology included follicular lysis, vascular proliferation, and lymphoid depletion. This study indicated that HIV-2(UC12) infection in baboons can cause HIV- associated pathological abnormalities within the lymphatic tissues and that the high level of HIV-2(UC12) replication in vitro was not predictive of replication in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0031984493&partnerID=8YFLogxK
U2 - 10.1089/aid.1998.14.79
DO - 10.1089/aid.1998.14.79
M3 - Article
C2 - 9453254
AN - SCOPUS:0031984493
SN - 0889-2229
VL - 14
SP - 79
EP - 82
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 1
ER -
