Treatment strategies and cumulative live birth rates in WHO-II ovulation disorders

Sanne C. Braam* (Corresponding Author), Jan Peter de Bruin, Erato T.I.A. Buisman, Monique Brandes, Willianne L.D.M. Nelen, Jesper M.J. Smeenk, Jan Willem van der Steeg, Ben Willem J. Mol, Carl J.C.M. Hamilton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective: To assess the live birth rate in women with WHO II anovulation and the proportion of women that need second or third line treatments if the initial therapy fails. Study design: In this multicenter cohort study we included couples with unfulfilled child wish who were referred to three fertility clinics in the Netherlands and selected women with a WHO II ovulation disorder as the only final infertility diagnosis (n = 468). Results: The cumulative live birth rate of the total group was 82% (383/468). The majority started with clomiphene-citrate as first-line treatment (n = 378) resulting in 180 (48%) live births. There were 153 couples (40%) who underwent a second-line treatment (recombinant-FSH or laparoscopic electrocoagulation of the ovaries, LEO) and 52 couples (14%) a third-line treatment (IVF/ICSI), resulting in 44% and 63% treatment dependent live births rates, respectively. Of all couples, 92 (20%) conceived naturally, 186 (40%) after clomiphene-citrate, 60 (13%) after recombinant-FSH, nine (2%) after LEO and 36 (8%) after IVF. Conclusion: Subfertile women with a WHO II ovulation disorder have a good prognosis on live birth, and most did so after ovulation induction with clomiphene-citrate. If first-line ovulation induction has failed ovulation induction with gonadotrophins or IVF still result in a live birth in about half of the cases.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Early online date10 Apr 2018
Publication statusPublished - 1 Jun 2018


  • Cumulative live birth rate
  • Infertility
  • Ovulation disorders


Dive into the research topics of 'Treatment strategies and cumulative live birth rates in WHO-II ovulation disorders'. Together they form a unique fingerprint.

Cite this