Tropic Orientation Responses of Pathogenic Fungi

Alex Brand, Neil Andrew Robert Gow

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)


Cellular orientation allows growth, differentiation and behaviour to respond to vectorial cues generated in the environment and in relation to cells of the same organisms or different organisms that exist in proximity to one another. In the case of fungal pathogens, the orientation of hyphae may allow the fungus to detect a host and to make strategic penetrations at points of weakness on the host surface. Within a host, tropic orientation may facilitate colonisation, ramification and dispersal within the host tissues. To achieve this, cells have to be able to coordinate their cell cycles, growth and expansion of their margins with directional growth responses. In this chapter, we review the tropic orientation responses of fungi and, with an emphasis on fungal pathogenesis, discuss and speculate on the underlying molecular mechanisms that regulate cellular tropisms. Examples are taken across the fungal kingdom, including from work on saprophytes, plant and animal pathogens, to construct a working model that speculates how a wide range of tropisms may be controlled by a more-or-less common tropic mechanism that regulates the orientation of the hyphal tip.
Original languageEnglish
Title of host publicationMorphogenesis and Pathogenicity in Fungi
EditorsJosé Pérez-Martín, Antonio Di Pietro
PublisherSpringer Berlin / Heidelberg
Number of pages21
ISBN (Print)9783642229152
Publication statusPublished - 2012

Publication series

NameTopics in Current Genetics
PublisherSpringer Berlin / Heidelberg
ISSN (Print)1610-2096
ISSN (Electronic)1610-6970


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