Urinary prostanoids in preschool wheeze

Jonathan Grigg; Abigail Whitehouse; Hitesh Pandya; Stephen Turner; Christopher J. Griffiths; Tom Vulliamy; Robert T. Walton; David B. Price; Marek Sanak; John W. Holloway; Lee Noimark; Maia Lesosky; Rossa Brugha; Lee Koh; Chinedu Nwokoro

doi:10.1183/13993003.01390-2016

Urinary prostanoids in preschool wheeze

Jonathan Grigg^*, Abigail Whitehouse, Hitesh Pandya, Stephen Turner, Christopher J. Griffiths, Tom Vulliamy, Robert T. Walton, David B. Price, Marek Sanak, John W. Holloway, Lee Noimark, Maia Lesosky, Rossa Brugha, Lee Koh, Chinedu Nwokoro

^*Corresponding author for this work

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Abstract

Acute episodes of wheeze in children of preschool age are frequently triggered by viral upper respiratory tract infections and result in a significant burden to health services [1]. However, to date, the inflammatory mechanisms underlying preschool wheeze remain unclear. Mediators that have not been studied in preschool wheeze, but are implicated in the pathogenesis of wheeze in adults with asthma, include the pro-inflammatory prostanoid prostaglandin D2 (PGD2) [2] and the anti-inflammatory prostanoid PGE2 [3, 4]. In this study, we sought evidence for either increased PGD2 biosynthesis or reduced PGE2 biosynthesis, or a combination of both in children with preschool wheeze. To achieve this, we measured the major metabolites of PGD2 and PGE2 in the urine: 9α-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGEM), respectively [5, 6].

Original language	English
Article number	1601390
Journal	European Respiratory Journal
Volume	49
Issue number	2
Early online date	2 Feb 2017
DOIs	https://doi.org/10.1183/13993003.01390-2016
Publication status	Published - Feb 2017

Bibliographical note

Support statement: Funding was received from the UK National Institute for Healthcare Research, Efficacy and Mechanisms Evaluation (NIHR-EME) Programme (reference 08/43/03). J. Grigg is part-funded by the NIHR North Thames Collaboration for Leadership in Applied Health Research and Care. Funding information for this article has been deposited with the Open Funder Registry.

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title = "Urinary prostanoids in preschool wheeze",

abstract = "Acute episodes of wheeze in children of preschool age are frequently triggered by viral upper respiratory tract infections and result in a significant burden to health services [1]. However, to date, the inflammatory mechanisms underlying preschool wheeze remain unclear. Mediators that have not been studied in preschool wheeze, but are implicated in the pathogenesis of wheeze in adults with asthma, include the pro-inflammatory prostanoid prostaglandin D2 (PGD2) [2] and the anti-inflammatory prostanoid PGE2 [3, 4]. In this study, we sought evidence for either increased PGD2 biosynthesis or reduced PGE2 biosynthesis, or a combination of both in children with preschool wheeze. To achieve this, we measured the major metabolites of PGD2 and PGE2 in the urine: 9α-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGEM), respectively [5, 6].",

author = "Jonathan Grigg and Abigail Whitehouse and Hitesh Pandya and Stephen Turner and Griffiths, {Christopher J.} and Tom Vulliamy and Walton, {Robert T.} and Price, {David B.} and Marek Sanak and Holloway, {John W.} and Lee Noimark and Maia Lesosky and Rossa Brugha and Lee Koh and Chinedu Nwokoro",

note = "Support statement: Funding was received from the UK National Institute for Healthcare Research, Efficacy and Mechanisms Evaluation (NIHR-EME) Programme (reference 08/43/03). J. Grigg is part-funded by the NIHR North Thames Collaboration for Leadership in Applied Health Research and Care. Funding information for this article has been deposited with the Open Funder Registry. ",

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doi = "10.1183/13993003.01390-2016",

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AU - Whitehouse, Abigail

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AU - Turner, Stephen

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AU - Vulliamy, Tom

AU - Walton, Robert T.

AU - Price, David B.

AU - Sanak, Marek

AU - Holloway, John W.

AU - Noimark, Lee

AU - Lesosky, Maia

AU - Brugha, Rossa

AU - Koh, Lee

AU - Nwokoro, Chinedu

N1 - Support statement: Funding was received from the UK National Institute for Healthcare Research, Efficacy and Mechanisms Evaluation (NIHR-EME) Programme (reference 08/43/03). J. Grigg is part-funded by the NIHR North Thames Collaboration for Leadership in Applied Health Research and Care. Funding information for this article has been deposited with the Open Funder Registry.

PY - 2017/2

Y1 - 2017/2

N2 - Acute episodes of wheeze in children of preschool age are frequently triggered by viral upper respiratory tract infections and result in a significant burden to health services [1]. However, to date, the inflammatory mechanisms underlying preschool wheeze remain unclear. Mediators that have not been studied in preschool wheeze, but are implicated in the pathogenesis of wheeze in adults with asthma, include the pro-inflammatory prostanoid prostaglandin D2 (PGD2) [2] and the anti-inflammatory prostanoid PGE2 [3, 4]. In this study, we sought evidence for either increased PGD2 biosynthesis or reduced PGE2 biosynthesis, or a combination of both in children with preschool wheeze. To achieve this, we measured the major metabolites of PGD2 and PGE2 in the urine: 9α-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGEM), respectively [5, 6].

AB - Acute episodes of wheeze in children of preschool age are frequently triggered by viral upper respiratory tract infections and result in a significant burden to health services [1]. However, to date, the inflammatory mechanisms underlying preschool wheeze remain unclear. Mediators that have not been studied in preschool wheeze, but are implicated in the pathogenesis of wheeze in adults with asthma, include the pro-inflammatory prostanoid prostaglandin D2 (PGD2) [2] and the anti-inflammatory prostanoid PGE2 [3, 4]. In this study, we sought evidence for either increased PGD2 biosynthesis or reduced PGE2 biosynthesis, or a combination of both in children with preschool wheeze. To achieve this, we measured the major metabolites of PGD2 and PGE2 in the urine: 9α-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGDM) and 9,15-dioxo-11α-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-1,20-dioic acid (tetranor-PGEM), respectively [5, 6].

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Urinary prostanoids in preschool wheeze

Abstract

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