Use of ovary culture techniques in reproductive toxicology

Agnes Stefansdottir, Paul A Fowler, Nicola Powles-Glover, Richard A Anderson, Norah Spears

Research output: Contribution to journalLiterature reviewpeer-review

35 Citations (Scopus)
11 Downloads (Pure)


There is increasing evidence to indicate that a substantial number of both man-made and naturally occurring chemicals are disruptive to human and wildlife reproductive health. Currently, reproductive toxicology testing is primarily carried out in vivo, however, in the past 50 years, various culture methods have been developed with the aim of growing ovarian follicles in vitro. These culture systems have become a widely used tool in reproductive biology and toxicology. In this review we describe how reproductive toxicology of the ovary is greatly enhanced by in vitro studies. Experiments using in vitro ovarian cultures to understand or detect damage to the ovary itself and to its specialised structures of the follicles and oocytes, allows for faster screening of potential developmental and/or reproductive toxicants.

Original languageEnglish
Pages (from-to)117-135
Number of pages19
JournalReproductive Toxicology
Early online date19 Aug 2014
Publication statusPublished - Nov 2014

Bibliographical note

Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
The author's studies in this field are supported by MRC grants G1002118 (NS and RAA) and G110357 (RAA), MR/L010011/1 (PAF), the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 212885 (PAF) and the Wellcome Trust (080388 to PAF). AS was funded by a BBSRC CASE Studentship co-funded by AstraZeneca.


  • ovary
  • follicle
  • tissue culture
  • in vitro
  • toxicology
  • pharmaceutical
  • EDC


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