Validity of using vision-related quality of life as a treatment end point in intermediate and posterior uveitis

Conor C. Murphy, Kathrin Greiner, Jarka Plskova, N. Andrew Frost, John V. Forrester, Andrew D. Dick

Research output: Contribution to journalArticle

38 Citations (Scopus)


Aim: To evaluate the responsiveness of the Vision core module 1 ( VCM1) vision-related quality of life ( VR-QOL) questionnaire to changes in visual acuity in patients with posterior and intermediate uveitis and to validate its use as a clinical end point in uveitis.

Methods: Logarithm of the minimum angle of resolution visual acuity and VR-QOL using the VCM1 questionnaire were prospectively recorded in 37 patients with active posterior segment intraocular inflammation before starting systemic immunosuppression with ciclosporin, tacrolimus or the antitumour necrosis factor ( TNF) agent, p55TNFr-Ig, and again 3 months later. Spearman analysis was used to correlate improvements in visual acuity and VR-QOL between baseline and 3 months.

Results: The correlation between changes in visual acuity and VR-QOL was moderate to good for the worse eye ( r = 0.47, p = 0.003), but poor for the better eye ( r = -0.05, p = 0.91). The responsiveness indices effect size and standardised response mean were 0.57 and 0.59, respectively, showing that the VCM1 questionnaire is moderately responsive to immunsosuppressive therapy for active uveitis.

Conclusion: Changes in VR-QOL measured with the VCM1 questionnaire correlated moderately well with changes in the worse eye visual acuity, suggesting that the VCM1 is a valid instrument for monitoring response to treatment in uveitis.

Original languageEnglish
Pages (from-to)154-156
Number of pages3
JournalBritish Journal of Ophthalmology
Issue number2
Early online date14 Sept 2006
Publication statusPublished - Feb 2007


  • visual function
  • general health
  • therapy


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