Variation at the GABAA receptor gene, rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder

Elaine K. Green, Detelina Grozeva, Valentina Moskvina, Marian L. Hamshere, Ian R. Jones, Lisa Jones, Liz Forty, Sian Caesar, Katherine Gordon-Smith, Christine Fraser, Ellie Russell, David St Clair, Allan H. Young, Nicol Ferrier, Anne Farmer, Peter McGuffin, Peter A. Holmans, Michael J. Owen, Michael C. O'Donovan, Nick Craddock

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


We have previously reported evidence that variation at GABAA receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052).

Original languageEnglish
Pages (from-to)1347-1349
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number7
Publication statusPublished - 1 Oct 2010

Bibliographical note

We are indebted to all individuals who have participated in our research. Funding for recruitment and phenotype assessment has been provided by the Wellcome Trust and the Medical Research Council. The GWAS genotype analyses were funded by the Wellcome Trust and undertaken within the context of the Wellcome Trust Case Control Consortium (WTCCC). The members of the WTCCC are listed below. Follow up genotyping was funded by the Wellcome Trust.


  • Bipolar disorder
  • GABA receptor
  • Genetics
  • Schizoaffective disorder


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