Variation in human water turnover associated with environmental and lifestyle factors

Yosuke Yamada; Xueying Zhang; Mary E T Henderson; Hiroyuki Sagayama; Herman Pontzer; Daiki Watanabe; Tsukasa Yoshida; Misaka Kimura; Philip N Ainslie; Lene F Andersen; Liam J Anderson; Lenore Arab; Issad Baddou; Kweku Bedu-Addo; Ellen E Blaak; Stephane Blanc; Alberto G Bonomi; Carlijn V C Bouten; Pascal Bovet; Maciej S Buchowski; Nancy F Butte; Stefan G Camps; Graeme L Close; Jamie A Cooper; Richard Cooper; Sai Krupa Das; Lara R Dugas; Simon Eaton; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W Fudge; Annelies H Goris; Michael Gurven; Lewis G Halsey; Catherine Hambly; Asmaa El Hamdouchi; Marije B Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M Joosen; Peter Katzmarzyk; Kitty P Kempen; William E Kraus; Wantanee Kriengsinyos; Robert F Kushner; Estelle V Lambert; William R Leonard; Nader Lessan; John R Speakman; International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

doi:10.1126/science.abm8668

Variation in human water turnover associated with environmental and lifestyle factors

Yosuke Yamada^* (Corresponding Author)
, Xueying Zhang
, Mary E T Henderson
, Hiroyuki Sagayama^* (Corresponding Author)
, Herman Pontzer^* (Corresponding Author)
, Daiki Watanabe
, Tsukasa Yoshida
, Misaka Kimura
, Philip N Ainslie
, Lene F Andersen
, Liam J Anderson
, Lenore Arab
, Issad Baddou
, Kweku Bedu-Addo
, Ellen E Blaak
, Stephane Blanc
, Alberto G Bonomi
, Carlijn V C Bouten
, Pascal Bovet
, Maciej S Buchowski

Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Lewis G Halsey, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, William E Kraus, Wantanee Kriengsinyos, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, John R Speakman^* (Corresponding Author), International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

^*Corresponding author for this work

National Institute of Health and Nutrition Tokyo
Chinese Academy of Sciences
University of Roehampton
University of Tsukuba
Duke University
Kyoto University of Advanced Science
University of British Columbia - Okanagan
University of Oslo
Liverpool John Moores University
University of California
Regional Designated Center of Nutrition Associated with AFRA/IAEA
Kwame Nkrumah University of Science and Technology
Maastricht University
University of Wisconsin-Madison
Philips Research
Unisanté Center for Primary Care and Public Health
Vanderbilt University
Baylor College of Medicine
University of Georgia
Loyola University Chicago
UCL Great Ormond Street Institute of Child Health
Norwegian School of Sport Sciences
The University of the West Indies
Aspire Academy
University of California at Santa Barbara
Beijing Technology and Business University
LSU Pennington Biomedical Research Center
Mahidol University
Northwestern University
University of Cape Town
Imperial College London
CAS - Institute of Genetics and Developmental Biology
Waseda University
University of Birmingham
Université de Strasbourg
Singapore Institute of Food and Biotechnology Innovation (SIFBI)
Tufts University
Norwegian Institute of Public Health
Charité – Universitätsmedizin Berlin
University of California at Irvine
Ministry of Health and Wellness
Imperial College London

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking ( 2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

Original language	English
Pages (from-to)	909-915
Number of pages	7
Journal	Science
Volume	378
Issue number	6622
Early online date	24 Nov 2022
DOIs	https://doi.org/10.1126/science.abm8668
Publication status	Published - 25 Nov 2022

Bibliographical note

Acknowledgments: We thank the International Atomic Energy Agency (IAEA), Taiyo Nippon Sanso, and SERCON for their support and T. Oono for his tremendous efforts at fundraising on our behalf. Y.Y., T.Y., and M.M. thank K. Abe for his support. Y.Y. and M.K. would like to pay gratitude and respect to their mentor, T. Morimoto, an emeritus professor of the Department of Physiology, Kyoto Prefectural University of Medicine, who passed away in July 2019.

Funding: The IAEA DLW Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding support for the database from the US National Science Foundation (grant BCS-1824466 to H.P.) and the Chinese Academy of Sciences (CAS grant 153E11KYSB20190045 to J.R.S.). The funders played no role in the content of this manuscript.

Data Availability Statement

All data used in these analyses are freely available on the IAEA DLW Database, which can be found at https://doubly-labelled-water-database.iaea.org/home or www.dlwdatabase.org.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 6 Clean Water and Sanitation
SDG 13 Climate Action

Keywords

Female
Pregnancy
Humans
Water
Life Style
Humidity
Exercise
Social Class
ADULTS
CLIMATE-CHANGE
HYDRATION
STRATEGIES
DENSITY
ENERGY-EXPENDITURE

Access to Document

10.1126/science.abm8668Licence: Unspecified

Cite this

Yamada, Y., Zhang, X., Henderson, M. E. T., Sagayama, H., Pontzer, H., Watanabe, D., Yoshida, T., Kimura, M., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., ... International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium (2022). Variation in human water turnover associated with environmental and lifestyle factors. Science, 378(6622), 909-915. https://doi.org/10.1126/science.abm8668

Yamada, Y, Zhang, X, Henderson, MET, Sagayama, H, Pontzer, H, Watanabe, D, Yoshida, T, Kimura, M, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SG, Close, GL, Cooper, JA, Cooper, R, Das, SK, Dugas, LR, Eaton, S, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Halsey, LG, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kraus, WE, Kriengsinyos, W, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Speakman, JR & International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium 2022, 'Variation in human water turnover associated with environmental and lifestyle factors', Science, vol. 378, no. 6622, pp. 909-915. https://doi.org/10.1126/science.abm8668

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title = "Variation in human water turnover associated with environmental and lifestyle factors",

abstract = "Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking ( 2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors. ",

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note = "Acknowledgments: We thank the International Atomic Energy Agency (IAEA), Taiyo Nippon Sanso, and SERCON for their support and T. Oono for his tremendous efforts at fundraising on our behalf. Y.Y., T.Y., and M.M. thank K. Abe for his support. Y.Y. and M.K. would like to pay gratitude and respect to their mentor, T. Morimoto, an emeritus professor of the Department of Physiology, Kyoto Prefectural University of Medicine, who passed away in July 2019. Funding: The IAEA DLW Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding support for the database from the US National Science Foundation (grant BCS-1824466 to H.P.) and the Chinese Academy of Sciences (CAS grant 153E11KYSB20190045 to J.R.S.). The funders played no role in the content of this manuscript.",

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AU - Yamada, Yosuke

AU - Zhang, Xueying

AU - Henderson, Mary E T

AU - Sagayama, Hiroyuki

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AU - Watanabe, Daiki

AU - Yoshida, Tsukasa

AU - Kimura, Misaka

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AU - International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium

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KW - HYDRATION

KW - STRATEGIES

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Variation in human water turnover associated with environmental and lifestyle factors

Abstract

Bibliographical note

Data Availability Statement

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Do We Really Need 8 Glasses of Water a Day? New Research Challenges Conventional Wisdom

Study examines amount of water people consume over their lifespan

Study reveals a wide variation in the water needs of people around the globe

Cite this

Variation in human water turnover associated with environmental and lifestyle factors

Abstract

Bibliographical note

Data Availability Statement

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Press/Media

Do We Really Need 8 Glasses of Water a Day? New Research Challenges Conventional Wisdom

Study examines amount of water people consume over their lifespan

Study reveals a wide variation in the water needs of people around the globe

Cite this