Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna Beedie; Alexandra J. Diamond; Lucas Rosa Fraga; William D. Figg; Neil Vargesson

doi:10.1016/j.reprotox.2016.11.013

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Shaunna Beedie
, Alexandra J. Diamond
, Lucas Rosa Fraga
, William D. Figg
, Neil Vargesson

Medical Sciences

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

26 Downloads (Pure)

Abstract

The development of new angiogenic inhibitors highlights a need for robust
screening assays that adequately capture the complexity of vessel formation,
and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic
agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

Original language	English
Pages (from-to)	49-59
Number of pages	10
Journal	Reproductive Toxicology
Volume	70
Early online date	22 Nov 2016
DOIs	https://doi.org/10.1016/j.reprotox.2016.11.013
Publication status	Published - 1 Jun 2017

Bibliographical note

Shaunna Beedie is a recipient of a Wellcome Trust-NIH PhD Studentship (Grant number 098252/Z/12/Z). Alexandra J. Diamond is a recipient of a BBSRC EastBIO DTP PhD Scholarship. Lucas Rosa Fraga is a recepient of a PhD scholarship from the Science Without Borders program – CNPq Brazil – INAGEMP/ Grant CNPq 573993/2008-4 Shaunna Beedie and William D. Figg are supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organization imply endorsement by the U.S. Government.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

angiogenesis
chicken
zebrafish
mouse
rat
rabbit
non-human primates
thalidomide

Access to Document

10.1016/j.reprotox.2016.11.013Licence: Unspecified

Accepted Manuscript
©2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 232 KBLicence: CC BY-NC-ND

Cite this

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title = "Vertebrate embryos as tools for anti-angiogenic drug screening and function",

abstract = "The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.",

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doi = "10.1016/j.reprotox.2016.11.013",

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AU - Vargesson, Neil

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N2 - The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

AB - The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new antiangiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.

KW - angiogenesis

KW - chicken

KW - zebrafish

KW - mouse

KW - rat

KW - rabbit

KW - non-human primates

KW - thalidomide

U2 - 10.1016/j.reprotox.2016.11.013

DO - 10.1016/j.reprotox.2016.11.013

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ER -

Vertebrate embryos as tools for anti-angiogenic drug screening and function

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Cite this