Vitamin B12 supplementation in end stage renal diseases: A systematic review

Maryam Amini; Maryam Khosravi; Hamid Reza Baradaran; Rasha Atlasi

Vitamin B12 supplementation in end stage renal diseases: A systematic review

Maryam Amini, Maryam Khosravi^*, Hamid Reza Baradaran, Rasha Atlasi

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients. Methods: Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial studies found during January 1999 to March 2014, we conducted a systematic review which assessed the effects of vitamin B12 in decreasing homocysteine levels in patients with ESRD. Results: The findings of this study revealed that, overall, the greatest effect of B12 supplementation on decreasing homocysteine levels in patients with ESRDs occurred when it was combined with folate supplementation. It was also demonstrated that injection treatments might be more beneficial than oral intake treatments. Conclusion: More rigorous studies are needed to draw a firm conclusion about B12 therapy and the level of homocyteine in patients with ESRD.

Original language	English
Article number	167
Number of pages	8
Journal	Medical Journal of the Islamic Republic of Iran
Volume	29
Early online date	27 Jan 2015
Publication status	Published - 2015

Bibliographical note

Acknowledgements
The authors wish to thank Hossein Ansari, Javad Tarrahi, Dr. Sakineh Shabbidar and Dr. Hadi Tabibi for their technical and valuable comments.

Keywords

Amino acids
Hemodialysis
Homocysteine
Kidney
Kidney failure
Renal failure
Review
Vitamin B12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Vitamin B12 supplementation in end stage renal diseases: a systematic review
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title = "Vitamin B12 supplementation in end stage renal diseases: A systematic review",

abstract = "Background: Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients. Methods: Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial studies found during January 1999 to March 2014, we conducted a systematic review which assessed the effects of vitamin B12 in decreasing homocysteine levels in patients with ESRD. Results: The findings of this study revealed that, overall, the greatest effect of B12 supplementation on decreasing homocysteine levels in patients with ESRDs occurred when it was combined with folate supplementation. It was also demonstrated that injection treatments might be more beneficial than oral intake treatments. Conclusion: More rigorous studies are needed to draw a firm conclusion about B12 therapy and the level of homocyteine in patients with ESRD.",

keywords = "Amino acids, Hemodialysis, Homocysteine, Kidney, Kidney failure, Renal failure, Review, Vitamin B12",

author = "Maryam Amini and Maryam Khosravi and Baradaran, {Hamid Reza} and Rasha Atlasi",

note = "Acknowledgements The authors wish to thank Hossein Ansari, Javad Tarrahi, Dr. Sakineh Shabbidar and Dr. Hadi Tabibi for their technical and valuable comments.",

year = "2015",

language = "English",

volume = "29",

journal = "Medical Journal of the Islamic Republic of Iran",

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publisher = "Iran University of Medical Sciences",

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T1 - Vitamin B12 supplementation in end stage renal diseases

T2 - A systematic review

AU - Amini, Maryam

AU - Khosravi, Maryam

AU - Baradaran, Hamid Reza

AU - Atlasi, Rasha

N1 - Acknowledgements The authors wish to thank Hossein Ansari, Javad Tarrahi, Dr. Sakineh Shabbidar and Dr. Hadi Tabibi for their technical and valuable comments.

PY - 2015

Y1 - 2015

N2 - Background: Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients. Methods: Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial studies found during January 1999 to March 2014, we conducted a systematic review which assessed the effects of vitamin B12 in decreasing homocysteine levels in patients with ESRD. Results: The findings of this study revealed that, overall, the greatest effect of B12 supplementation on decreasing homocysteine levels in patients with ESRDs occurred when it was combined with folate supplementation. It was also demonstrated that injection treatments might be more beneficial than oral intake treatments. Conclusion: More rigorous studies are needed to draw a firm conclusion about B12 therapy and the level of homocyteine in patients with ESRD.

AB - Background: Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients. Methods: Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial studies found during January 1999 to March 2014, we conducted a systematic review which assessed the effects of vitamin B12 in decreasing homocysteine levels in patients with ESRD. Results: The findings of this study revealed that, overall, the greatest effect of B12 supplementation on decreasing homocysteine levels in patients with ESRDs occurred when it was combined with folate supplementation. It was also demonstrated that injection treatments might be more beneficial than oral intake treatments. Conclusion: More rigorous studies are needed to draw a firm conclusion about B12 therapy and the level of homocyteine in patients with ESRD.

KW - Amino acids

KW - Hemodialysis

KW - Homocysteine

KW - Kidney

KW - Kidney failure

KW - Renal failure

KW - Review

KW - Vitamin B12

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M3 - Article

AN - SCOPUS:84930711158

SN - 1016-1430

VL - 29

JO - Medical Journal of the Islamic Republic of Iran

JF - Medical Journal of the Islamic Republic of Iran

M1 - 167

ER -

Vitamin B12 supplementation in end stage renal diseases: A systematic review

Abstract

Bibliographical note

Keywords

UN SDGs

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