Will advances in fish immunology change vaccination strategies?

Chris Secombes

Research output: Contribution to journalArticle

77 Citations (Scopus)


This review will discuss some of the recent advances in discovering immune genes in fish, in terms of their relevance to vaccine design and development. Particular emphasis will. be placed on the many cytokine and costimulatory molecules now known, with examples drawn from the mammalian literature as to their potential value for fish vaccinology. A new area of vaccine research will also be touched upon, where efficacious responses are elicited by inhibiting the natural negative regulators of immune responses, such as Treg cell products and SOCS proteins. (c) 2008 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)409-416
Number of pages8
JournalFish & Shellfish Immunology
Issue number4
Early online date16 May 2008
Publication statusPublished - Oct 2008


  • vaccination
  • cytokines
  • costimulatory molecules
  • molecular adjuvants
  • trout oncorhynchus-mykiss
  • NF-Kappa-B
  • grwoth-factor-beta
  • flounder paralichthys-olivaceus
  • colony-stimulating factor
  • expression analysis
  • teleost fish
  • Japanese flounder
  • functional-characterization
  • antigen presentation


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