GLP-1R agonist Treatment of Bscl2-null Mouse model of CGL2

Description

Data resulting from studying the potential therapeutic benefits of GLP-1R agonists (here liraglutide) in lipoatrophic diabetes. Here Seipin-deficient Bscl2 null mice, modelling Congenital Generalised Lipodystrophy Type 2 (CGL2) were treated acutely or for 14 days with liraglutide. Assessments of glucose tolerance, insulin tolerance, pyruvate tolerance were made as well as determination of changes to hepatic steatosis, insulin secretion, pancreas histology and appetite regulation.

Data type

Excel data sheets and image files

Dataset version

1.0

Date made available	6 Feb 2024
Publisher	University of Aberdeen

Funder and Grant Reference number

Other
Diabetes UK:18/0005884
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/V015869/1

Contact

[email protected]

DOI
10.20392/aef8fe2e-5180-4693-b187-750dfecf5e9e

Access Dataset

Figure_1_Acute_Tolerance_Tests.xlsx
File: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 25.2 KB
Type: Dataset
Figure_2_Metabolic_Assessment.xlsx
File: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 33.1 KB
Type: Dataset
Figure_3_Liver_Analysis.xlsx
File: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 24.6 KB
Type: Dataset
Figure 3C H&E liver Female_SKO_Lira_857.czi
File: application/octet-stream, 484 MB
Type: Image
Figure 3C H&E liver Female_SKO_PBS_819.czi
File: application/octet-stream, 500 MB
Type: Image
Figure 3C H&E liver Female_WT_Lira_809.czi
File: application/octet-stream, 410 MB
Type: Image
Figure 3C H&E liver Female_WT_PBS_808.czi
File: application/octet-stream, 508 MB
Type: Image
Figure 3D H&E liver Male_SKO_Lira_806.czi
File: application/octet-stream, 402 MB
Type: Image
Figure 3D H&E liver Male_SKO_PBS_811.czi
File: application/octet-stream, 463 MB
Type: Image
Figure 3D H&E liver Male_WT_Lira_842.czi
File: application/octet-stream, 436 MB
Type: Image
Figure 3D H&E liver Male_WT_PBS_843.czi
File: application/octet-stream, 266 MB
Type: Image
Figure 3C Liver macroscopy female_SKO_LIRA.JPG
File: image/jpeg, 3.61 MB
Type: Image
Figure 3C Liver macroscopy female_SKO_PBS.JPG
File: image/jpeg, 3.58 MB
Type: Image
Figure 3C Liver macroscopy female_WT_LIRA.JPG
File: image/jpeg, 3.37 MB
Type: Image
Figure 3C Liver macroscopy female_WT_PBS.JPG
File: image/jpeg, 3.33 MB
Type: Image
Figure 3D Liver macroscopy male_SKO_LIRA.JPG
File: image/jpeg, 3.69 MB
Type: Image
Figure 3D Liver macroscopy male_SKO_PBS.JPG
File: image/jpeg, 3.52 MB
Type: Image
Figure 3D Liver macroscopy male_WT_LIRA.JPG
File: image/jpeg, 3.79 MB
Type: Image
Figure 3D Liver macroscopy male_WT_PBS.JPG
File: image/jpeg, 3.74 MB
Type: Image
Figure 3C Picrosirius red liver Female_SKO_LIRA_637.czi
File: application/octet-stream, 24.2 MB
Type: Image
Figure 3C Picrosirius red liver Female_SKO_PBS_639_c.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 3C Picrosirius red liver Female_WT_LIRA_598.czi
File: application/octet-stream, 24.2 MB
Type: Image
Figure 3C Picrosirius red liver Female_WT_PBS_597_c.czi
File: application/octet-stream, 24.2 MB
Type: Image
Figure 3D Picrosirius red liver Male_SKO_LIRA_603_b.czi
File: application/octet-stream, 24.2 MB
Type: Image
Figure 3D Picrosirius red liver Male_SKO_PBS_854_a.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 3D Picrosirius red liver Male_WT_LIRA_610_a.czi
File: application/octet-stream, 24.2 MB
Type: Image
Figure 3D Picrosirius red liver Male_WT_PBS_588_c.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure_4_Insulin_Pancreas_Analysis.xlsx
File: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 25 KB
Type: Dataset
Figure 4B Pancreas Insulin DAB Female_SKO_LIRA_647.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Female_SKO_PBS_650.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Female_WT_LIRA_652.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Female_WT_PBS_649.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Male_SKO_LIRA_645.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Male_SKO_PBS_641.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Male_WT_LIRA_631.czi
File: application/octet-stream, 24.1 MB
Type: Image
Figure 4B Pancreas Insulin DAB Male_WT_PBS_655.czi
File: application/octet-stream, 24.1 MB
Type: Image

https://abdn.elsevierpure.com/en/datasets/aef8fe2e-5180-4693-b187-750dfecf5e9e

1 Article

GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy
Roumane, A., Mcilroy, G. D., Sommer, N., Han, W., Heisler, L. K. & Rochford, J. J., 30 Apr 2024, In: Frontiers in Endocrinology. 15, 11 p., 1379228.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

6 Downloads (Pure)

Cite this

Rochford, J. (Creator) (6 Feb 2024). GLP-1R agonist Treatment of Bscl2-null Mouse model of CGL2. University of Aberdeen. Figure_1_Acute_tolerance_tests(.xlsx), Figure_2(.xlsx), Figure_3_liver(.xlsx), Female_SKO_Lira_857(.czi), Female_SKO_PBS_819(.czi), Female_WT_Lira_809(.czi), Female_WT_PBS_808(.czi), Male_SKO_Lira_806(.czi), Male_SKO_PBS_811(.czi), Male_WT_Lira_842(.czi), Male_WT_PBS_843(.czi), female_SKO_LIRA(.JPG), female_SKO_PBS(.JPG), female_WT_LIRA(.JPG), female_WT_PBS(.JPG), male_SKO_LIRA(.JPG), male_SKO_PBS(.JPG), male_WT_LIRA(.JPG), male_WT_PBS(.JPG), Female_SKO_LIRA_637(.czi), Female_SKO_PBS_639_c(.czi), Female_WT_LIRA_598(.czi), Female_WT_PBS_597_c(.czi), Male_SKO_LIRA_603_b(.czi), Male_SKO_PBS_854_a(.czi), Male_WT_LIRA_610_a(.czi), Male_WT_PBS_588_c(.czi), Figure_4_insulin_pancreas(.xlsx), Female_SKO_LIRA_647(.czi), Female_SKO_PBS_650(.czi), Female_WT_LIRA_652(.czi), Female_WT_PBS_649(.czi), Male_SKO_LIRA_645(.czi), Male_SKO_PBS_641(.czi), Male_WT_LIRA_631(.czi), Male_WT_PBS_655(.czi). 10.20392/aef8fe2e-5180-4693-b187-750dfecf5e9e