Felix Grassmann

Research output

Research output per year 2011 2014 2015 2017 2018 2019 2020 2021 2024

• 54 Article
• 2 Chapter
• 2 Review article
• 1 Letter

Research output per year

Research output per year

Search results

• Article

  A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD)

  Grassmann, F., Friedrich, U., Fauser, S., Schick, T., Milenkovic, A., Schulz, H. L., von Strachwitz, C. N., Bettecken, T., Lichtner, P., Meitinger, T., Arend, N., Wolf, A., Haritoglou, C., Rudolph, G., Chakravarthy, U., Silvestri, G., McKay, G. J., Freitag-Wolf, S., Krawczak, M., Smith, R. T., & 5 othersMerriam, J. C., Merriam, J. E., Allikmets, R., Heid, I. M. & Weber, B. H. F., 1 Jun 2015, In: NeuroMolecular Medicine. 17, 2, p. 111-120 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Association Studies 100%
  • Macular Degeneration 98%
  • Haplotypes 44%
  • Single Nucleotide Polymorphism 39%
  • Proteins 34%
  26 Citations (Scopus)

• A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization

  Kiel, C., Berber, P., Karlstetter, M., Aslanidis, A., Strunz, T., Langmann, T., Grassmann, F. & Weber, B. H. F., Apr 2020, In: International Journal of Molecular Sciences. 21, 8, 2689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • angiogenesis 100%
  • Circulating MicroRNA 93%
  • Choroidal Neovascularization 83%
  • MicroRNA 81%
  • mice 69%
  8 Citations (Scopus)

  5 Downloads (Pure)

• A circulating MicroRNA profile is associated with late- stage neovascular age-related macular degeneration

  Grassmann, F., Schoenberger, P. G. A., Brandl, C., Schick, T., Hasler, D., Meister, G., Fleckenstein, M., Lindner, M., Helbig, H., Fauser, S. & Weber, B. H. F., 9 Sept 2014, In: PloS ONE. 9, 9, e0107461.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • macular degeneration 100%
  • Circulating MicroRNA 94%
  • MicroRNA 82%
  • Macular Degeneration 70%
  • microRNA 68%
  63 Citations (Scopus)

• A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography

  Grassmann, F., Mengelkamp, J., Brandl, C., Harsch, S., Zimmermann, M. E., Linkohr, B., Peters, A., Heid, I. M., Palm, C. & Weber, B. H. F., 10 Apr 2018, In: Ophthalmology. 125, 9, p. 1410-1420 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Deep Learning 100%
  • Photography 85%
  • Macular Degeneration 76%
  • Eye Diseases 75%
  • Color 60%
  365 Citations (Scopus)

  8 Downloads (Pure)

• A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry

  CTS Consortium, 9 Aug 2023, In: Breast Cancer Research. 25, 1, p. 93

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene-Environment Interaction 100%
  • Genome 54%
  • Breast Neoplasms 51%
  • Single Nucleotide Polymorphism 20%
  • Life Style 13%
  2 Citations (Scopus)

  1 Downloads (Pure)

• Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator

  Micklisch, S., Lin, Y., Jacob, S., Karlstetter, M., Dannhausen, K., Dasari, P., von der Heide, M., Dahse, H. M., Schmölz, L., Grassmann, F., Alene, M., Fauser, S., Neumann, H., Lorkowski, S., Pauly, D., Weber, B. H., Joussen, A. M., Langmann, T., Zipfel, P. F. & Skerka, C., 5 Jan 2017, In: Journal of Neuroinflammation. 14, 15 p., 4.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hereditary Complement Deficiency Diseases 100%
  • Macular Degeneration 68%
  • Monocytes 45%
  • Properdin 34%
  • Microglia 33%
  79 Citations (Scopus)

  3 Downloads (Pure)

• A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

  Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., Kim, I. K., Cho, D., Zack, D., Souied, E., Scholl, H. P. N., Bala, E., ELee, K., Hunter, D. J., Sardell, R. J., Mitchell, P., & 142 othersMerriam, J. E., Cipriani, V., Hoffman, J. D., Schick, T., Lechanteur, Y. T. E., Guymer, R. H., Johnson, M. P., Jiang, Y., Stanton, C. M., Buitendijk, G. H. S., Zhan, X., Kwong, A. M., Boleda, A., Brooks, M., Gieser, L., Ratnapriya, R., Branham, K. E., Foerster, J. R., Heckenlively, J. R., Othman, M. I., Vote, B. J., Liang, H. H., Souzeau, E., McAllister, I. L., Isaacs, T., Hall, J., Lake, S., Mackey, D. A., Constable, I. J., Craig, J. E., Kitchner, T. E., Yang, Z., Su, Z., Luo, H., Chen, D., Ouyang, H., Flagg, K., Lin, D., Mao, G., Ferreyra, H., Stark, K., Von Strachwitz, C. N., Wolf, A., Brandl, C., Rudolph, G., Olden, M., Morrison, M. A., Morgan, D. J., Schu, M., Ahn, J., Silvestri, G., Tsironi, E. E., Park, K. H., Farrer, L. A., Orlin, A., Brucker, A., Li, M., Curcio, C. A., Mohand-Sa'd, S., Sahel, J. A., Audo, I., Benchaboune, M., Cree, A. J., Rennie, C. A., Goverdhan, S. V., Grunin, M., Hagbi-Levi, S., Campochiaro, P., Katsanis, N., Holz, F. G., Blond, F., Blanché, H., Deleuze, J. F. O., Igo, R. P., Truitt, B., Peachey, N. S., Meuer, S. M., Myers, C. E., Moore, E. L., Klein, R., Hauser, M. A., Postel, E. A., Courtenay, M. D., Schwartz, S. G., Kovach, J. L., Scott, W. K., Liew, G., Tan, A. G., Gopinath, B., Merriam, J. C., Smith, R. T., Khan, J. C., Shahid, H., Moore, A. T., McGrath, J. A., Laux, R., Brantley, M. A., Agarwal, A., Ersoy, L., Caramoy, A., Langmann, T., Saksens, N. T. M., Jong, E. K., Hoyng, C. B., Cain, M. S., Richardson, A. J., Martin, T. M., Blangero, J., Weeks, D. E., Dhillon, B., Van Duijn, C. M., Doheny, K. F., Romm, J., Klaver, C. C. W., Hayward, C., Gorin, M. B., Klein, M. L., Baird, P. N., Den Hollander, A. I., Fauser, S., Yates, J. R., Allikmets, R., Wang, J. J., Schaumberg, D. A., Klein, B. E. K., Hagstrom, S. A., Chowers, I., Lotery, A. J., Léveillard, T., Zhang, K., Brilliant, M. H., Hewitt, A. W., Swaroop, A., Chew, E. Y., Pericak-Vance, M. A., DeAngelis, M., Stambolian, D., Haines, J. L., Iyengar, S. K., Weber, B. H. F., Abecasis, G. R. & Heid, I. M., Feb 2016, In: Nature Genetics. 48, p. 134-143 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Macular Degeneration 100%
  • Genome-Wide Association Study 99%
  • chemotactic factor inactivator 45%
  • Genetic Loci 38%
  • Blindness 33%
  1037 Citations (Scopus)

• A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver

  Strunz, T., Grassmann, F., Gayán, J., Nahkuri, S., Souza-Costa, D., Maugeais, C., Fauser, S., Nogoceke, E. & Weber, B. H. F., 12 Apr 2018, In: Scientific Reports. 8, 11 p., 5865.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quantitative Trait Loci 100%
  • Regulator Genes 82%
  • Gene Expression 47%
  • Liver 40%
  • Macular Degeneration 35%
  42 Citations (Scopus)

  5 Downloads (Pure)

• A mega-analysis of expression quantitative trait loci in retinal tissue

  Strunz, T., Kiel, C., Grassmann, F., Ratnapriya, R., Kwicklis, M., Karlstetter, M., Fauser, S., Arend, N., Swaroop, A., Langmann, T., Wolf, A. & Weber, B. H. F., 1 Sept 2020, In: PLoS Genetics. 16, 9, p. e1008934 18 p., e1008934.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Quantitative Trait Loci 100%
  • eye disease 80%
  • quantitative trait loci 69%
  • eye diseases 68%
  • tissue 56%
  16 Citations (Scopus)

• An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans

  McEwan, A. R., Hing, B., Erickson, J. C., Hutchings, G., Urama, C., Norton-Hughes, E., D'Ippolito, M., Berry, S., Delibegovic, M., Grassmann, F. & MacKenzie, A., 16 Jan 2024, (E-pub ahead of print) In: Molecular Psychiatry. 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nucleic Acid Regulatory Sequences 100%
  • Brain-Derived Neurotrophic Factor 91%
  • Anxiety 62%
  • Obesity 60%
  • Genes 35%

• Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration

  Grassmann, F., Harsch, S., Brandl, C., Kiel, C., Nürnberg, P., Toliat, M. R., Fleckenstein, M., Pfau, M., Schmitz-Valckenberg, S., Holz, F. G., Chew, E. Y., Swaroop, A., Ratnapriya, R., Klein, M. L., Mulyukov, Z., Zamiri, P. & Weber, B. H. F., 2019, In: JAMA Ophthalmology. 137, 8, p. 867-876 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Geographic Atrophy 100%
  • Macular Degeneration 69%
  • Genome 45%
  • Growth 33%
  • Genes 26%
  31 Citations (Scopus)

• Association between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns

  Ugalde-Morales, E., Grassmann, F., Humphreys, K., Li, J., Eriksson, M., Tobin, N. P., Borg, Å., Vallon-Christersson, J., Hall, P. & Czene, K., 15 Feb 2021, In: International Journal of Cancer. 148, 4, p. 884-894 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breast Diseases 100%
  • Breast Neoplasms 51%
  • Gene Expression 48%
  • Neoplasms 18%
  • Survival 12%
  4 Citations (Scopus)

  2 Downloads (Pure)

• A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

  International AMD Genomics Consortium (IAMDGC), 31 Jan 2020, In: Scientific Reports. 10, 16 p., 1584.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macular Degeneration 100%
  • Transcriptome 87%
  • Pathology 60%
  • Genes 38%
  • Gene Expression 32%
  31 Citations (Scopus)

  3 Downloads (Pure)

• Bedeutung des komplementsystems für die altersabhängige makuladegeneration

  Translated title of the contribution: The role of the complement system in age-related macular degenerationWeber, B. H. F., Charbel Issa, P., Pauly, D., Herrmann, P., Grassmann, F. & Holz, F. G., 21 Feb 2014, In: Deutsches Arzteblatt International. 111, 8, p. 133-138 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Macular Degeneration 100%
  • lampalizumab 29%
  • Clinical Trials 26%
  • Complement Factor D 21%
  • Geographic Atrophy 20%
  48 Citations (Scopus)

• Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration

  Grassmann, F., Fleckenstein, M., Chew, E. Y., Strunz, T., Schmitz-Valckenberg, S., Göbel, A. P., Klein, M. L., Ratnapriya, R., Swaroop, A., Holz, F. G. & Weber, B. H. F., 11 May 2015, In: PloS ONE. 10, 5, e0126636.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Geographic Atrophy 100%
  • macular degeneration 98%
  • atrophy 74%
  • Macular Degeneration 69%
  • genetic factors 67%
  62 Citations (Scopus)

• Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy) Neuro-ophthalmology

  Grassmann, F., Bergholz, R., Mändl, J., Jägle, H., Ruether, K. & Weber, B. H., 2015, In: BMC Ophthalmology. 15, 7 p., 18.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chloroquine 100%
  • Macular Degeneration 92%
  • Ophthalmology 92%
  • Poisons 65%
  • Hydroxychloroquine 26%
  38 Citations (Scopus)

  3 Downloads (Pure)

• Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial

  Liao, D. S., Grossi, F. V., El Mehdi, D., Gerber, M. R., Brown, D. M., Heier, J. S., Wykoff, C. C., Singerman, L. J., Abraham, P., Grassmann, F., Nuernberg, P., Weber, B. H. F., Deschatelets, P., Kim, R. Y., Chung, C. Y., Ribeiro, R. M., Hamdani, M., Rosenfeld, P. J., Boyer, D. S., Slakter, J. S., & 1 othersFrancois, C. G., Feb 2020, In: Ophthalmology. 127, 2, p. 186-195 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Geographic Atrophy 100%
  • Complement Inactivating Agents 96%
  • Complement C3 82%
  • Macular Degeneration 69%
  • Visual Acuity 20%
  315 Citations (Scopus)

  4 Downloads (Pure)

• Cost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease

  Khan, M., Cornelis, S. S., Khan, M. I., Elmelik, D., Manders, E., Bakker, S., Derks, R., Neveling, K., van de Vorst, M., Gilissen, C., Meunier, I., Defoort, S., Puech, B., Devos, A., Schulz, H. L., Stöhr, H., Grassmann, F., Weber, B. H. F., Dhaenens, C. M. & Cremers, F. P. M., Oct 2019, In: Human Mutation. 40, 10, p. 1749-1759 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Stargardt Disease 100%
  • Molecular Probes 87%
  • High-Throughput Nucleotide Sequencing 62%
  • Costs and Cost Analysis 40%
  • Mutation 36%
  36 Citations (Scopus)

• CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial

  He, W., Eriksson, M., Eliasson, E., Grassmann, F., Bäcklund, M., Gabrielson, M., Hammarström, M., Margolin, S., Thorén, L., Wengström, Y., Borgquist, S., Hall, P. & Czene, K., 1 Oct 2021, In: Annals of Oncology. 32, 10, p. 1286-1293 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytochrome P-450 CYP2D6 100%
  • Tamoxifen 84%
  • Genotype 56%
  • Breast Density 36%
  • Pharmaceutical Preparations 32%
  13 Citations (Scopus)

  1 Downloads (Pure)

• CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer

  He, W., Grassmann, F., Eriksson, M., Eliasson, E., Margolin, S., Thorén, L., Hall, P. & Czene, K., 20 Feb 2020, In: Journal of Clinical Oncology. 38, 6, p. 548-557 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytochrome P-450 CYP2D6 100%
  • Tamoxifen 84%
  • Genotype 56%
  • Breast Neoplasms 50%
  • Retrospective Studies 7%
  31 Citations (Scopus)

• Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance

  Hägg, S., Jylhävä, J., Wang, Y., Czene, K. & Grassmann, F., Jun 2021, In: Human Genetics. 140, p. 849-861 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondrial DNA 100%
  • Mitochondrial Genome 13%
  • Erythrocyte Count 13%
  • Hematologic Diseases 12%
  • Frailty 12%
  38 Citations (Scopus)

  16 Downloads (Pure)

• Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides

  Sangermano, R., Garanto, A., Khan, M., Runhart, E. H., Bauwens, M., Bax, N. M., van den Born, L. I., Khan, M. I., Cornelis, S. S., Verheij, J. B. G. M., Pott, J. W. R., Thiadens, A. A. H. J., Klaver, C. C. W., Puech, B., Meunier, I., Naessens, S., Arno, G., Fakin, A., Carss, K. J., Raymond, F. L., & 10 othersWebster, A. R., Dhaenens, C. M., Stöhr, H., Grassmann, F., Weber, B. H. F., Hoyng, C. B., De Baere, E., Albert, S., Collin, R. W. J. & Cremers, F. P. M., Aug 2019, In: Genetics in Medicine. 21, 8, p. 1751-1760 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stargardt Disease 100%
  • Antisense Oligonucleotides 74%
  • RNA Splice Sites 40%
  • Exome 38%
  • Inborn Genetic Diseases 29%
  132 Citations (Scopus)

  3 Downloads (Pure)

• Distinct genetic risk profile of the rapidly progressing diffuse-trickling subtype of geographic atrophy in age-related macular degeneration (AMD)

  Fleckenstein, M., Grassmann, F., Lindner, M., Pfau, M., Czauderna, J., Strunz, T., von Strachwitz, C., Schmitz-Valckenberg, S., Holz, F. G. & Weber, B. H. F., May 2016, In: Investigative Ophthalmology and Visual Science. 57, 6, p. 2463-2471 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Geographic Atrophy 100%
  • Genetic Profile 86%
  • Macular Degeneration 69%
  • Phenotype 10%
  • Late-Onset Retinal Degeneration 8%
  21 Citations (Scopus)

• Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration

  Pujol-Lereis, L. M., Liebisch, G., Schick, T., Lin, Y., Grassmann, F., Uchida, K., Zipfel, P. F., Fauser, S., Skerka, C. & Weber, B. H. F., 2 Aug 2018, In: PloS ONE. 13, 8, 20 p., e0200739.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • macular degeneration 100%
  • Sphingolipid 88%
  • sphingolipids 84%
  • ceramides 83%
  • Sphingolipids 82%
  18 Citations (Scopus)

  3 Downloads (Pure)

• Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study

  Brandl, C., Breinlich, V., Stark, K. J., Enzinger, S., Aenmacher, M., Olden, M., Grassmann, F., Graw, J., Heier, M., Peters, A., Helbig, H., Küchenhoff, H., Weber, B. H. F. & Heid, I. M., 28 Nov 2016, In: PloS ONE. 11, 11, 19 p., e0167181.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • macular degeneration 100%
  • Macular Degeneration 70%
  • Metabolic 54%
  • Smoking 48%
  • gender 41%
  29 Citations (Scopus)

  4 Downloads (Pure)

• Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

  International AMD Genomics Consortium (IAMDGC), Mar 2017, In: Genome Medicine. 9, 13 p., 29.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Pleiotropy 100%
  • Multifactorial Inheritance 77%
  • Macular Degeneration 65%
  • Autoimmune Diseases 9%
  • Lipid Metabolism Disorders 7%
  48 Citations (Scopus)

  2 Downloads (Pure)

• Genetic risk models in age-related macular degeneration

  Grassmann, F., Heid, I. M. & Weber, B. H. F., 2014, In: Advances in Experimental Medicine and Biology. 801, p. 291-300 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Models 100%
  • Macular Degeneration 93%
  • Strength 56%
  • Retina 25%
  • Smoking 21%
  7 Citations (Scopus)

• Genetisches Risiko bei der altersabhängigen Makuladegeneration

  Translated title of the contribution: Genetic risk in age-related macular degenerationGrassmann, F., Loss, J., Heid, I. M. & Weber, B. H. F., 12 Nov 2015, In: BioSpektrum. 21, 7, p. 703-705 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Macular Degeneration 100%
  • Blindness 49%
  • Therapeutics 7%
  1 Citation (Scopus)

• Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

  Winkler, T. W., Grassmann, F., Brandl, C., Kiel, C., Günther, F., Strunz, T., Weidner, L., Zimmermann, M. E., Korb, C. A., Poplawski, A., Schuster, A. K., Müller-Nurasyid, M., Peters, A., Rauscher, F. G., Elze, T., Horn, K., Scholz, M., Cañadas-Garre, M., McKnight, A. J., Quinn, N., & 5 othersHogg, R. E., Küchenhoff, H., Heid, I. M., Stark, K. J. & Weber, B. H. F., 26 Aug 2020, In: BMC Medical Genomics. 13, 18 p., 120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macular Degeneration 100%
  • Genome-Wide Association Study 99%
  • Meta-Analysis 71%
  • Joints 6%
  • Genome 6%
  55 Citations (Scopus)

  4 Downloads (Pure)

• In-depth characterisation of retinal pigment epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC)

  Brandl, C., Zimmermann, S. J., Milenkovic, V. M., Rosendahl, S. M. G., Grassmann, F., Milenkovic, A., Hehr, U., Federlin, M., Wetzel, C. H., Helbig, H. & Weber, B. H. F., Sept 2014, In: NeuroMolecular Medicine. 16, 3, p. 551-564 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Retinal Pigment Epithelium 100%
  • Induced Pluripotent Stem Cells 98%
  • Fibroblasts 23%
  • Skin 13%
  • Cytophagocytosis 10%
  62 Citations (Scopus)

• Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data

  International AMD Genomics Consortium (IAMDGC), Mar 2020, In: Human Genetics. 139, p. 401-407 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Y Chromosome 100%
  • Macular Degeneration 86%
  • Cytogenetics 32%
  • Sex Chromosomes 21%
  • Statistical Models 18%
  16 Citations (Scopus)

• Interval breast cancer is associated with other types of tumors

  Grassmann, F., He, W., Eriksson, M., Gabrielson, M., Hall, P. & Czene, K., 22 Oct 2019, In: Nature Communications. 10, 9 p., 4648.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • breast 100%
  • tumors 90%
  • cancer 88%
  • Mutation 80%
  • intervals 69%
  22 Citations (Scopus)

  4 Downloads (Pure)

• Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci

  International Age-related Macular Degeneration Genomics Consortium (IAMDGC), 12 Mar 2018, In: PloS ONE. 13, 3, 21 p., e0194321.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • macular degeneration 100%
  • Macular Degeneration 70%
  • loci 41%
  • gender 41%
  • Retinal 38%
  20 Citations (Scopus)

  3 Downloads (Pure)

• Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study

  Luo, J., Noordam, R., Jukema, J. W., Willems van Dijk, K., Hägg, S., Grassmann, F., le Cessie, S. & van Heemst, D., 2 May 2023, In: Cardiovascular Research. 119, 4, p. 998-1007 10 p., cvac182.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial DNA 100%
  • Random Allocation 93%
  • Coronary Artery Disease 78%
  • Mendelian Randomization Analysis 76%
  • Leukocytes 75%
  2 Citations (Scopus)

• Lymph node metastases in breast cancer: investigating associations with tumor characteristics, molecular subtypes, and polygenic risk score using a continuous growth model

  Isheden, G., Grassmann, F., Czene, K. & Humphreys, K., 15 Sept 2021, In: International Journal of Cancer. 149, 6, p. 1348-1357 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lymph Nodes 100%
  • Breast Neoplasms 89%
  • Neoplasm Metastasis 86%
  • Growth 70%
  • Neoplasms 45%
  7 Citations (Scopus)

  3 Downloads (Pure)

• Mammographic features are associated with cardiometabolic disease risk and mortality

  Grassmann, F., Yang, H., Eriksson, M., Azam, S., Hall, P. & Czene, K., 2 Aug 2021, In: European Heart Journal. 42, 34, p. 3361–3370 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Calcinosis 100%
  • Mortality 60%
  • Preexisting Condition Coverage 47%
  • Siblings 36%
  • Women's Health 21%
  11 Citations (Scopus)

  9 Downloads (Pure)

• Modelling the genetic risk in age-related macular degeneration

  Grassmann, F., Fritsche, L. G., Keilhauer, C. N., Heid, I. M. & Weber, B. H. F., 30 May 2012, In: PloS ONE. 7, 5, 10 p., e37979.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • macular degeneration 100%
  • Macular Degeneration 70%
  • Population 8%
  • taxonomy 8%
  • loci 6%
  73 Citations (Scopus)

• Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)

  Grassmann, F., Cantsilieris, S., Schulz-Kuhnt, A. S., White, S. J., Richardson, A. J., Hewitt, A. W., Vote, B. J., Schmied, D., Guymer, R. H., Weber, B. H. F. & Baird, P. N., 18 Apr 2016, In: Journal of Neuroinflammation. 13, 9 p., 81.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Complement C4a 100%
  • Macular Degeneration 52%
  • Genes 20%
  • Complement C4 11%
  • Gene Components 11%
  25 Citations (Scopus)

  4 Downloads (Pure)

• Mutation spectrum of the ABCA4 gene in 335 stargardt disease patients from a multicenter German cohort—impact of selected deep intronic variants and common SNPs

  Schulz, H. L., Grassmann, F., Kellner, U., Spital, G., Rüther, K., Jägle, H., Hufendiek, K., Rating, P., Huchzermeyer, C., Baier, M. J., Weber, B. H. F. & Stöhr, H., Jan 2017, In: Investigative Ophthalmology and Visual Science. 58, 1, p. 394-403 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stargardt Disease 100%
  • Single Nucleotide Polymorphism 54%
  • Alleles 37%
  • Mutation 36%
  • Genes 26%
  106 Citations (Scopus)

• Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

  Kiel, C., International AMD Genomics Consortium (IAMDGC), Strunz, T., Grassmann, F. & Weber, B. H. F., 8 Oct 2020, In: Cells. 9, 10, 18 p., 2257.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Pressure 100%
  • Cytochrome P450 84%
  • Macular Degeneration 82%
  • Binding Site 55%
  • Cytochrome P-450 CYP1A1 39%
  4 Citations (Scopus)

  3 Downloads (Pure)

• Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration

  Ratnapriya, R., Zhan, X., Fariss, R. N., Branham, K. E., Zipprer, D., Chakarova, C. F., Sergeev, Y. V., Campos, M. M., Othman, M., Friedman, J. S., Maminishkis, A., Waseem, N. H., Brooks, M., Rajasimha, H. K., Edwards, A. O., Lotery, A., Klein, B. E., Truitt, B. J., Li, B., Schaumberg, D. A., & 47 othersMorgan, D. J., Morrison, M. A., Souied, E., Tsironi, E. E., Grassmann, F., Fishman, G. A., Silvestri, G., Scholl, H. P. N., Kim, I. K., Ramke, J., Tuo, J., Merriam, J. E., Merriam, J. C., Park, K. H., Olson, L. M., Farrer, L. A., Johnson, M. P., Peachey, N. S., Lathrop, M., Baron, R. V., Igo, R. P., Klein, R., Hagstrom, S. A., Kamatani, Y., Martin, T. M., Jiang, Y., Conley, Y., Sahel, J. A., Zack, D. J., Chan, C. C., Pericak-Vance, M. A., Jacobson, S. G., Gorin, M. B., Klein, M. L., Allikmets, R., Iyengar, S. K., Weber, B. H., Haines, J. L., Léveillard, T., Deangelis, M. M., Stambolian, D., Weeks, D. E., Bhattacharya, S. S., Chew, E. Y., Heckenlively, J. R., Abecasis, G. R. & Swaroop, A., 1 Nov 2014, In: Human Molecular Genetics. 23, 21, p. 5827-5837 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibrillin-2 100%
  • Macular Degeneration 58%
  • Extracellular Matrix 47%
  • Genes 22%
  • Elastin 21%
  52 Citations (Scopus)

• Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration

  International AMD Genomics Consortium (IAMDGC), Feb 2017, In: Genetics. 205, 2, p. 919-924 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macular Degeneration 100%
  • Haplotypes 89%
  • Genes 19%
  • Blindness 16%
  • Genomics 16%
  58 Citations (Scopus)

  2 Downloads (Pure)

• Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (CFH) gene family

  Cantsilieris, S., Nelson, B. J., Huddleston, J., Baker, C., Harshman, L., Penewit, K., Munson, K. M., Sorensen, M., Welch, A. M. E., Dang, V., Grassmann, F., Richardson, A. J., Guymer, R. H., Graves-Lindsay, T. A., Wilson, R. K., Weber, B. H. F., Baird, P. N., Allikmets, R. & Eichler, E. E., 8 May 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. E4433-E4442 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Complement Factor H 100%
  • Mya 52%
  • Macular Degeneration 46%
  • Genes 29%
  • Primates 27%
  38 Citations (Scopus)

  5 Downloads (Pure)

• Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513

  Kiel, C., Strunz, T., Hasler, D., Meister, G., Grassmann, F. & Weber, B. H. F., 15 Mar 2022, In: Human Molecular Genetics. 31, 6, p. 875-887 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • human MIRN-4513 microRNA 100%
  • Seeds 40%
  • Alleles 29%
  • Genes 16%
  • MicroRNAs 13%
  1 Citation (Scopus)

  3 Downloads (Pure)

• Spectral domain optical coherence tomography allows the unification of clinical decision making for the evaluation of choroidal neovascularization activity

  Volz, C., Grassmann, F., Greslechner, R., Märker, D. A., Peters, P., Helbig, H. & Gamulescu, M. A., Dec 2018, In: Ophthalmologica. 241, 1, p. 32-37 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Choroidal Neovascularization 100%
  • Clinical Decision-Making 84%
  • Optical Coherence Tomography 80%
  • Macular Degeneration 27%
  • Vascular Endothelial Growth Factor A 23%
  4 Citations (Scopus)

• Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-βsignaling

  Friedrich, U., Datta, S., Schubert, T., Plössl, K., Schneider, M., Grassmann, F., Fuchshofer, R., Tiefenbach, K. J., Längst, G. & Weber, B. H. F., 15 Nov 2015, In: Human Molecular Genetics. 24, 22, p. 6361-6373 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Macular Degeneration 100%
  • Temperature 68%
  • Transforming Growth Factors 50%
  • Plasminogen Activator Inhibitor 1 35%
  • Protein Isoforms 25%
  44 Citations (Scopus)

• The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia

  Mages, K., Grassmann, F., Jägle, H., Rupprecht, R., Weber, B. H. F., Hauck, S. M. & Grosche, A., 18 Feb 2019, In: Journal of Neuroinflammation. 16, 16 p., 43.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide 100%
  • Retinal Neurons 65%
  • Neuroglia 43%
  • Retina 42%
  • Microglia 37%
  35 Citations (Scopus)

  6 Downloads (Pure)

• The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses

  Martens, L. G., Luo, J., Wermer, M. J. H., Willems van Dijk, K., Hägg, S., Grassmann, F., Noordam, R. & van Heemst, D., 1 Aug 2022, In: Atherosclerosis. 354, p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mendelian Randomization Analysis 100%
  • Mitochondrial DNA 65%
  • Stroke 42%
  • Survival 34%
  • Random Allocation 17%
  5 Citations (Scopus)

  3 Downloads (Pure)

• The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study

  Sartor, H., Brandt, J., Grassmann, F., Eriksson, M., Czene, K., Melander, O. & Zackrisson, S., 1 Oct 2020, In: Acta radiologica (Stockholm, Sweden : 1987). 61, 10, p. 1326-1334 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breast Density 100%
  • Single Nucleotide Polymorphism 61%
  • Diet 50%
  • Breast Neoplasms 46%
  • Survival 40%
  6 Citations (Scopus)

  3 Downloads (Pure)

• The genetics of age-related macular degeneration (AMD) - Novel targets for designing treatment options?

  Grassmann, F., Fauser, S. & Weber, B. H. F., 1 Sept 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 95, Part B, p. 194-202 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Macular Degeneration 100%
  • Therapeutics 15%
  • Investigational Therapies 14%
  • Blindness 12%
  • Developed Countries 11%
  34 Citations (Scopus)