Genetic risk models in age-related macular degeneration

Felix Grassmann; Iris M. Heid; Bernhard H.F. Weber

doi:10.1007/978-1-4614-3209-8_37

Genetic risk models in age-related macular degeneration

Felix Grassmann, Iris M. Heid, Bernhard H.F. Weber^*

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Late-stage age-related macular degeneration (AMD) is a common sightthreatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.

Original language	English
Pages (from-to)	291-300
Number of pages	10
Journal	Advances in Experimental Medicine and Biology
Volume	801
Early online date	25 Mar 2014
DOIs	https://doi.org/10.1007/978-1-4614-3209-8_37
Publication status	Published - 2014

Bibliographical note

Keywords

Age-related macular degeneration
Cox regression
Genetic risk score
Logistic regression
Susceptibility

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10.1007/978-1-4614-3209-8_37

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title = "Genetic risk models in age-related macular degeneration",

abstract = "Late-stage age-related macular degeneration (AMD) is a common sightthreatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.",

keywords = "Age-related macular degeneration, Cox regression, Genetic risk score, Logistic regression, Susceptibility",

author = "Felix Grassmann and Heid, {Iris M.} and Weber, {Bernhard H.F.}",

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AU - Grassmann, Felix

AU - Heid, Iris M.

AU - Weber, Bernhard H.F.

N1 - © Springer Science+Business Media, LLC 2014

PY - 2014

Y1 - 2014

N2 - Late-stage age-related macular degeneration (AMD) is a common sightthreatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.

AB - Late-stage age-related macular degeneration (AMD) is a common sightthreatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.

KW - Age-related macular degeneration

KW - Cox regression

KW - Genetic risk score

KW - Logistic regression

KW - Susceptibility

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DO - 10.1007/978-1-4614-3209-8_37

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SN - 0065-2598

VL - 801

SP - 291

EP - 300

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Genetic risk models in age-related macular degeneration

Abstract

Bibliographical note

Keywords

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