5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

Kirsty E. A. Muirhead; Laurent Trembleau; William T. A. Harrison

doi:10.1107/S1600536807031285

5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

Kirsty E. A. Muirhead, Laurent Trembleau, William T. A. Harrison

Chemistry

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

In the title compound, C17H22ClN3O2, the aromatic fused ring system and the amide group are close to being coplanar [dihedral angle = 14.66 (16)degrees]. Thus, the amide NH group is sterically blocked from forming a hydrogen bond by the pendant ethyl substituent of the adjacent five-membered ring. The NH group of the five-membered ring makes an intermolecular N-H center dot center dot center dot O bond, resulting in centrosymmetric dimers of molecules containing R-2(2)(10)loops.

Original language	English
Article number	o3389
Number of pages	11
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	63
Issue number	8
DOIs	https://doi.org/10.1107/S1600536807031285
Publication status	Published - 1 Aug 2007

Keywords

X-ray
diffraction

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10.1107/S1600536807031285

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title = "5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide",

abstract = "In the title compound, C17H22ClN3O2, the aromatic fused ring system and the amide group are close to being coplanar [dihedral angle = 14.66 (16)degrees]. Thus, the amide NH group is sterically blocked from forming a hydrogen bond by the pendant ethyl substituent of the adjacent five-membered ring. The NH group of the five-membered ring makes an intermolecular N-H center dot center dot center dot O bond, resulting in centrosymmetric dimers of molecules containing R-2(2)(10)loops.",

keywords = "X-ray, diffraction",

author = "Muirhead, {Kirsty E. A.} and Laurent Trembleau and Harrison, {William T. A.}",

year = "2007",

month = aug,

day = "1",

doi = "10.1107/S1600536807031285",

language = "English",

volume = "63",

journal = "Acta Crystallographica Section E: Structure Reports Online",

issn = "1600-5368",

publisher = "International Union of Crystallography",

number = "8",

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TY - JOUR

T1 - 5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

AU - Muirhead, Kirsty E. A.

AU - Trembleau, Laurent

AU - Harrison, William T. A.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - In the title compound, C17H22ClN3O2, the aromatic fused ring system and the amide group are close to being coplanar [dihedral angle = 14.66 (16)degrees]. Thus, the amide NH group is sterically blocked from forming a hydrogen bond by the pendant ethyl substituent of the adjacent five-membered ring. The NH group of the five-membered ring makes an intermolecular N-H center dot center dot center dot O bond, resulting in centrosymmetric dimers of molecules containing R-2(2)(10)loops.

AB - In the title compound, C17H22ClN3O2, the aromatic fused ring system and the amide group are close to being coplanar [dihedral angle = 14.66 (16)degrees]. Thus, the amide NH group is sterically blocked from forming a hydrogen bond by the pendant ethyl substituent of the adjacent five-membered ring. The NH group of the five-membered ring makes an intermolecular N-H center dot center dot center dot O bond, resulting in centrosymmetric dimers of molecules containing R-2(2)(10)loops.

KW - X-ray

KW - diffraction

U2 - 10.1107/S1600536807031285

DO - 10.1107/S1600536807031285

M3 - Article

SN - 1600-5368

VL - 63

JO - Acta Crystallographica Section E: Structure Reports Online

JF - Acta Crystallographica Section E: Structure Reports Online

IS - 8

M1 - o3389

ER -

5-chloro-3-ethyl-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide

Abstract

Keywords

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