A core outcome set for future research in ectopic pregnancy: an international consensus development study

International Collaboration on Core Outcomes in Ectopic Pregnancy

doi:10.1016/j.fertnstert.2023.01.042

A core outcome set for future research in ectopic pregnancy: an international consensus development study

International Collaboration on Core Outcomes in Ectopic Pregnancy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: To address methodological deficiencies in published randomized controlled trials and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy (EP). Design: To identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in EP. Potential core outcomes were then entered into a 3-round Delphi survey. A total of 154 participants from 6 continents, comprising health care professionals, researchers, and individuals with lived experience in EP, completed all 3 rounds of the Delphi survey. Outcomes were prioritized at 3 consensus development meetings, and recommendations were developed on how to report these outcomes where possible. Setting: Not applicable. Patient(s): Health care professionals, researchers, and individuals with lived experience in EP. Intervention(s): Not applicable. Main Outcome Measure(s): Consensus for inclusion in core outcome set. Result(s): Six outcomes reached full consensus, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction. Conclusion(s): The core outcome set with 6 outcomes for EP will help standardize reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient-centered care.

Original language	English
Pages (from-to)	804-812
Number of pages	9
Journal	Fertility and Sterility
Volume	119
Issue number	5
Early online date	1 Feb 2023
DOIs	https://doi.org/10.1016/j.fertnstert.2023.01.042
Publication status	Published - May 2023

Bibliographical note

Funding Information:
K.Y.C. has nothing to disclose. S.S. has nothing to disclose. K.B. has nothing to disclose. P.C.-A. reports grants from the National Institutes of Health / National Cancer Institute Cancer Centre Support Grant P30 CA008748. P.C. has nothing to disclose. G.C. has nothing to disclose. L.d.W. has nothing to disclose. J.M.N.D. has nothing to disclose. A.W.H. has received honoraria for consultancy for Ferring , Roche , Nordic Pharma , and AbbVie . M.M. has nothing to disclose. F.M. has nothing to disclose. M.O. has nothing to disclose. R.P. has nothing to disclose. A.S. has nothing to disclose. M.v.W. reports leading the Netherlands Satellite of the Cochrane Gynaecology and Fertility Group. J.v.H. has nothing to disclose. L.N.V. reports other from Merck , grants and other from Merck Sharp and Dohme , and grants and other from Ferring , outside the submitted work. J.Z. has nothing to disclose. D.J. has nothing to disclose. B.W.M. reports grants from the National Health and National Health and Medical Research Council , other from ObsEva, and grants from Guerbet and Merck , outside the submitted work.

Keywords

consensus methods
Core outcome set
ectopic pregnancy

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10.1016/j.fertnstert.2023.01.042Licence: Unspecified

Cite this

@article{43a8331aaa654bb09073f01ba354c5a7,

title = "A core outcome set for future research in ectopic pregnancy: an international consensus development study",

abstract = "Objective: To address methodological deficiencies in published randomized controlled trials and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy (EP). Design: To identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in EP. Potential core outcomes were then entered into a 3-round Delphi survey. A total of 154 participants from 6 continents, comprising health care professionals, researchers, and individuals with lived experience in EP, completed all 3 rounds of the Delphi survey. Outcomes were prioritized at 3 consensus development meetings, and recommendations were developed on how to report these outcomes where possible. Setting: Not applicable. Patient(s): Health care professionals, researchers, and individuals with lived experience in EP. Intervention(s): Not applicable. Main Outcome Measure(s): Consensus for inclusion in core outcome set. Result(s): Six outcomes reached full consensus, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction. Conclusion(s): The core outcome set with 6 outcomes for EP will help standardize reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient-centered care.",

keywords = "consensus methods, Core outcome set, ectopic pregnancy",

author = "Chong, {Krystle Y.} and Sarah Solangon and Kurt Barnhart and Pamela Causa-Andrieu and Perrine Capmas and George Condous and {de Waard}, Liesl and Duffy, {James M.N.} and Horne, {Andrew W.} and Maria Memtsa and Femke Mol and Munira Oza and Romina Pesce and Annika Strandell and {van Wely}, Madelon and {van't Hooft}, Janneke and Vuong, {Lan N.} and Jian Zhang and Davor Jurkovic and Mol, {Ben W.} and {International Collaboration on Core Outcomes in Ectopic Pregnancy}",

note = "Funding Information: K.Y.C. has nothing to disclose. S.S. has nothing to disclose. K.B. has nothing to disclose. P.C.-A. reports grants from the National Institutes of Health / National Cancer Institute Cancer Centre Support Grant P30 CA008748. P.C. has nothing to disclose. G.C. has nothing to disclose. L.d.W. has nothing to disclose. J.M.N.D. has nothing to disclose. A.W.H. has received honoraria for consultancy for Ferring , Roche , Nordic Pharma , and AbbVie . M.M. has nothing to disclose. F.M. has nothing to disclose. M.O. has nothing to disclose. R.P. has nothing to disclose. A.S. has nothing to disclose. M.v.W. reports leading the Netherlands Satellite of the Cochrane Gynaecology and Fertility Group. J.v.H. has nothing to disclose. L.N.V. reports other from Merck , grants and other from Merck Sharp and Dohme , and grants and other from Ferring , outside the submitted work. J.Z. has nothing to disclose. D.J. has nothing to disclose. B.W.M. reports grants from the National Health and National Health and Medical Research Council , other from ObsEva, and grants from Guerbet and Merck , outside the submitted work. ",

year = "2023",

month = may,

doi = "10.1016/j.fertnstert.2023.01.042",

language = "English",

volume = "119",

pages = "804--812",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "ACADEMIC PRESS INC ELSEVIER SCIENCE",

number = "5",

}

TY - JOUR

T1 - A core outcome set for future research in ectopic pregnancy

T2 - an international consensus development study

AU - Chong, Krystle Y.

AU - Solangon, Sarah

AU - Barnhart, Kurt

AU - Causa-Andrieu, Pamela

AU - Capmas, Perrine

AU - Condous, George

AU - de Waard, Liesl

AU - Duffy, James M.N.

AU - Horne, Andrew W.

AU - Memtsa, Maria

AU - Mol, Femke

AU - Oza, Munira

AU - Pesce, Romina

AU - Strandell, Annika

AU - van Wely, Madelon

AU - van't Hooft, Janneke

AU - Vuong, Lan N.

AU - Zhang, Jian

AU - Jurkovic, Davor

AU - Mol, Ben W.

AU - International Collaboration on Core Outcomes in Ectopic Pregnancy

N1 - Funding Information: K.Y.C. has nothing to disclose. S.S. has nothing to disclose. K.B. has nothing to disclose. P.C.-A. reports grants from the National Institutes of Health / National Cancer Institute Cancer Centre Support Grant P30 CA008748. P.C. has nothing to disclose. G.C. has nothing to disclose. L.d.W. has nothing to disclose. J.M.N.D. has nothing to disclose. A.W.H. has received honoraria for consultancy for Ferring , Roche , Nordic Pharma , and AbbVie . M.M. has nothing to disclose. F.M. has nothing to disclose. M.O. has nothing to disclose. R.P. has nothing to disclose. A.S. has nothing to disclose. M.v.W. reports leading the Netherlands Satellite of the Cochrane Gynaecology and Fertility Group. J.v.H. has nothing to disclose. L.N.V. reports other from Merck , grants and other from Merck Sharp and Dohme , and grants and other from Ferring , outside the submitted work. J.Z. has nothing to disclose. D.J. has nothing to disclose. B.W.M. reports grants from the National Health and National Health and Medical Research Council , other from ObsEva, and grants from Guerbet and Merck , outside the submitted work.

PY - 2023/5

Y1 - 2023/5

N2 - Objective: To address methodological deficiencies in published randomized controlled trials and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy (EP). Design: To identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in EP. Potential core outcomes were then entered into a 3-round Delphi survey. A total of 154 participants from 6 continents, comprising health care professionals, researchers, and individuals with lived experience in EP, completed all 3 rounds of the Delphi survey. Outcomes were prioritized at 3 consensus development meetings, and recommendations were developed on how to report these outcomes where possible. Setting: Not applicable. Patient(s): Health care professionals, researchers, and individuals with lived experience in EP. Intervention(s): Not applicable. Main Outcome Measure(s): Consensus for inclusion in core outcome set. Result(s): Six outcomes reached full consensus, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction. Conclusion(s): The core outcome set with 6 outcomes for EP will help standardize reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient-centered care.

AB - Objective: To address methodological deficiencies in published randomized controlled trials and systematic reviews, this study has developed a core outcome set to guide future research in ectopic pregnancy (EP). Design: To identify potential outcomes, we performed a comprehensive literature review and interviews with individuals with lived experience in EP. Potential core outcomes were then entered into a 3-round Delphi survey. A total of 154 participants from 6 continents, comprising health care professionals, researchers, and individuals with lived experience in EP, completed all 3 rounds of the Delphi survey. Outcomes were prioritized at 3 consensus development meetings, and recommendations were developed on how to report these outcomes where possible. Setting: Not applicable. Patient(s): Health care professionals, researchers, and individuals with lived experience in EP. Intervention(s): Not applicable. Main Outcome Measure(s): Consensus for inclusion in core outcome set. Result(s): Six outcomes reached full consensus, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction. Conclusion(s): The core outcome set with 6 outcomes for EP will help standardize reporting of clinical trials, facilitate implementation of findings into clinical practice, and enhance patient-centered care.

KW - consensus methods

KW - Core outcome set

KW - ectopic pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85151491675&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2023.01.042

DO - 10.1016/j.fertnstert.2023.01.042

M3 - Article

C2 - 36736812

AN - SCOPUS:85151491675

SN - 0015-0282

VL - 119

SP - 804

EP - 812

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -

A core outcome set for future research in ectopic pregnancy: an international consensus development study

Abstract

Bibliographical note

Keywords

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