A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease

Mohammad Sadegh Khorrami; Fatemeh Sadabadi; Alireza Pasdar; Hamide Safarian-Bana; Forouzan Amerizadeh; Habibollah Esmaeily; Mohsen Moohebati; Alireza Heidari-Bakavoli; Gordon Ferns; Majid Ghayour-Mobarhan; Amir Avan

doi:10.52547/rbmb.10.4.653

A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease

Mohammad Sadegh Khorrami, Fatemeh Sadabadi, Alireza Pasdar, Hamide Safarian-Bana, Forouzan Amerizadeh, Habibollah Esmaeily, Mohsen Moohebati, Alireza Heidari-Bakavoli, Gordon Ferns, Majid Ghayour-Mobarhan^*, Amir Avan

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.

METHODS: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method.

RESULTS: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data.

CONCLUSION: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.

Original language	English
Pages (from-to)	653-663
Number of pages	11
Journal	Reports of Biochemistry and Molecular Biology
Volume	10
Issue number	4
Early online date	1 Jan 2022
DOIs	https://doi.org/10.52547/rbmb.10.4.653
Publication status	Published - 7 Feb 2022

Bibliographical note

Funding Information:
We thank all the patients and their family members who volunteered to participate in this study. This work was supported by the Deputy of Research, Mashhad University of Medical Sciences (Grant number 931753).

Publisher Copyright:
© 2022. All Rights Reserved.

Keywords

Cardiovascular diseases
Cohort studies
Genetic Polymorphism
PSRC1 Gene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Khorrami, M. S., Sadabadi, F., Pasdar, A., Safarian-Bana, H., Amerizadeh, F., Esmaeily, H., Moohebati, M., Heidari-Bakavoli, A., Ferns, G., Ghayour-Mobarhan, M., & Avan, A. (2022). A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease. Reports of Biochemistry and Molecular Biology, 10(4), 653-663. https://doi.org/10.52547/rbmb.10.4.653

Khorrami, MS, Sadabadi, F, Pasdar, A, Safarian-Bana, H, Amerizadeh, F, Esmaeily, H, Moohebati, M, Heidari-Bakavoli, A, Ferns, G, Ghayour-Mobarhan, M & Avan, A 2022, 'A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease', Reports of Biochemistry and Molecular Biology, vol. 10, no. 4, pp. 653-663. https://doi.org/10.52547/rbmb.10.4.653

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abstract = "BACKGROUND: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.METHODS: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method.RESULTS: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data.CONCLUSION: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.",

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note = "Funding Information: We thank all the patients and their family members who volunteered to participate in this study. This work was supported by the Deputy of Research, Mashhad University of Medical Sciences (Grant number 931753). Publisher Copyright: {\textcopyright} 2022. All Rights Reserved.",

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doi = "10.52547/rbmb.10.4.653",

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T1 - A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease

AU - Khorrami, Mohammad Sadegh

AU - Sadabadi, Fatemeh

AU - Pasdar, Alireza

AU - Safarian-Bana, Hamide

AU - Amerizadeh, Forouzan

AU - Esmaeily, Habibollah

AU - Moohebati, Mohsen

AU - Heidari-Bakavoli, Alireza

AU - Ferns, Gordon

AU - Ghayour-Mobarhan, Majid

AU - Avan, Amir

N1 - Funding Information: We thank all the patients and their family members who volunteered to participate in this study. This work was supported by the Deputy of Research, Mashhad University of Medical Sciences (Grant number 931753). Publisher Copyright: © 2022. All Rights Reserved.

PY - 2022/2/7

Y1 - 2022/2/7

N2 - BACKGROUND: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.METHODS: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method.RESULTS: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data.CONCLUSION: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.

AB - BACKGROUND: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.METHODS: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method.RESULTS: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data.CONCLUSION: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.

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KW - Cohort studies

KW - Genetic Polymorphism

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JO - Reports of Biochemistry and Molecular Biology

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A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease

Abstract

Bibliographical note

Keywords

UN SDGs

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