A Human Ex Vivo Skin Model to Study Candida auris Biofilms

Dora E Corzo-León, Catherine Mark, Donna M MacCallum, Carol A Munro

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Candida auris can persist for long periods on hospital surfaces and on the skin. C. auris has the ability to form drug-resistant biofilms, which can substantially impact on patient outcome. In comparison to Candida albicans, C. auris has a lower capacity to form biofilms in in vitro models and a higher capacity when tested on animal skin models. Intraspecies variation is shown to exist, with some clinical isolates having greater biofilm capabilities than others. There is a need for models that closely mimic the real niches where infection occurs on human patients. This protocol describes, in detail, a human skin model to study C. auris biofilm formation using catheterized and non-catheterized skin.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalMethods in molecular biology (Clifton, N.J.)
Publication statusPublished - 9 Jun 2022

Bibliographical note

This project was funded by a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377) and Medical Research Council Centre for Medical Mycology (MR/N006364/1), previously at the University of Aberdeen, now at the University of Exeter.


  • Animals
  • Antifungal Agents/pharmacology
  • Biofilms
  • Candida
  • Candida albicans
  • Candida auris
  • Candidiasis/drug therapy
  • Humans


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