TY - JOUR
T1 - A multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy
T2 - the TURRIFIC randomised trial
AU - Hague, William M.
AU - Callaway, Leonie
AU - Chambers, Jennifer
AU - Chappell, Lucy
AU - Coat, Suzette
AU - de Haan-Jebbink, Jiska
AU - Dekker, Marloes
AU - Dixon, Peter
AU - Dodd, Jodie
AU - Fuller, Maria
AU - Gordijn, Sanne
AU - Graham, Dorothy
AU - Heikinheimo, Oskari
AU - Hennessy, Annemarie
AU - Kaaja, Risto
AU - Khong, Teck Yee
AU - Lampio, Laura
AU - Louise, Jennie
AU - Makris, Angela
AU - Markus, Corey
AU - Marschall, Hanns-Ulrich
AU - Middleton, Philippa
AU - Mol, Ben W.
AU - Morris, Jonathan
AU - Newnham, John P.
AU - Ovadia, Caroline
AU - Peek, Michael
AU - Shand, Antonia
AU - Stark, Michael
AU - Thornton, Jim
AU - Timonen, Susanna
AU - Walker, Susan
AU - Warrilow, David
AU - Williamson, Catherine
N1 - Funding
The study sponsor and the funder (National Health and Medical Research Council (NHMRC) Medical Research Future Fund (MRFF) Lifting Clinical Trials and Registries Capacity (LCTRC) Grant Opportunity) have had no role in the study design; the collection, management, analysis, and interpretation of the data; the final writing of the report; and the decision to submit the report for publication.
PY - 2021
Y1 - 2021
N2 - Severe early onset (less than 34 weeks gestation) intrahepatic cholestasis of pregnancy (ICP) affects 0.1% of pregnant women in Australia and is associated with a 3-fold increased risk of stillbirth, fetal hypoxia and compromise, spontaneous preterm birth, as well as increased frequencies of pre-eclampsia and gestational diabetes. ICP is often familial and overlaps with other cholestatic disorders.
AB - Severe early onset (less than 34 weeks gestation) intrahepatic cholestasis of pregnancy (ICP) affects 0.1% of pregnant women in Australia and is associated with a 3-fold increased risk of stillbirth, fetal hypoxia and compromise, spontaneous preterm birth, as well as increased frequencies of pre-eclampsia and gestational diabetes. ICP is often familial and overlaps with other cholestatic disorders.
KW - Intrahepatic cholestasis of pregnancy
KW - Cholestatic pruritus
KW - Bile acids
KW - Ursodeoxycholic acid
KW - Rifampicin
KW - Maternal and neonatal health outcomes
U2 - 10.1186/s12884-020-03481-y
DO - 10.1186/s12884-020-03481-y
M3 - Article
C2 - 33435904
SN - 1471-2393
VL - 21
JO - BMC Pregnancy and Childbirth
JF - BMC Pregnancy and Childbirth
IS - 1
M1 - 51
ER -