TY - JOUR
T1 - A new tetrahydrofuran derivative from the Endophytic Fungus Chaetomium sp. isolated from Otanthus maritimus
AU - Aly, A.H.
AU - Debbab, A.
AU - Edrada-Ebel, R.
AU - Wray, V.
AU - Müller, W.E.G.
AU - Lin, W.
AU - Ebel, R.
AU - Proksch, P.
N1 - Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009/6
Y1 - 2009/6
N2 - A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activ-ity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC values of 7.0 and 2.7 µg/mL, respectively, whereas 1 was inactive.
AB - A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activ-ity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC values of 7.0 and 2.7 µg/mL, respectively, whereas 1 was inactive.
UR - http://www.scopus.com/inward/record.url?scp=70349324814&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:70349324814
SN - 0939-5075
VL - 64
SP - 350
EP - 354
JO - Zeitschrift für Naturforschung - C
JF - Zeitschrift für Naturforschung - C
IS - 5-6
ER -