A novel cryptosystem using DNA sequencing and contextual array splicing system for Medical Internet of Things

Indumathi Ugandran, Anand Mahendran, Anandakumar S., Mohammed Hamada, Waleed S. Alnumay, Uttam Ghosh, Pradip Kumar Sharma*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


In the modern world, there is a huge increase in the usage of various technologies which may produce heterogeneous data. Using the latest security algorithms like Triple Data Encryption Standard (TDES), Rivest Shamir Adleman (RSA), Advanced Encryption Standard (AES) these (heterogeneous) data are transferred over the internet. Despite of such good security mechanisms, there exist vulnerabilities to the user data. In the recent years, researchers started the usage of bio-inspired computing models towards security. In this paper, two such bio-inspired computing models namely splicing system and Deoxyribonucleic acid (DNA) sequencing were used. We proposed a novel cryptosystem using contextual array splicing system for DNA sequenced input data. In this process, we have designed Turing machine(s) that perform(s) the conversion of a binary input to DNA sequence and the cryptosystem operation using contextual array splicing system. Next, the developed novel cryptosystem is applied in the domain of Medical Internet of Things (MIoT). Further, we had investigated the proof of correctness. Next, the proposed cryptosystems are proved to be Turing computable. Finally, the security analysis and evaluation of the proposed cryptosystem has been studied.

Original languageEnglish
Article number107429
Number of pages16
JournalComputers and Electrical Engineering
Issue numberpart A
Early online date13 Oct 2021
Publication statusPublished - 1 Dec 2021

Bibliographical note

Funding Information:
Anand Mahendran would like to acknowledge the project No: 25(0291)/18/EMR-II , Council of Scientific and Industrial Research (CSIR), New Delhi, India . Waleed Alnumay acknowledge Researchers Supporting Project number ( RSP-2021/250 ), King Saud University, Riyadh, Saudi Arabia to support this work.


  • Decryption
  • DNA computing
  • Encryption
  • MIoT
  • Splicing system
  • Turing machine


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