Abstract
There is growing recognition of the importance of integrating drug occupancy data acquired by positron emission tomography (PET) with the plasma pharmacokinetics of the drug, in order to establish proper dose selection in subsequent clinical trials. Here we present a study in human subjects of the occupancy of NK(1) receptors achieved following different doses of casopitant, a selective NK(1) antagonist.
Original language | English |
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Pages (from-to) | 226-235 |
Number of pages | 10 |
Journal | European Journal of Nuclear Medicine and Molecular Imaging |
Volume | 39 |
Issue number | 2 |
Early online date | 13 Oct 2011 |
DOIs | |
Publication status | Published - Feb 2012 |
Keywords
- positron emission tomography
- pharmacokinetics
- NK1 receptors
- kinetic modelling
- population approach