A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

Ayşe Selcen Semerciöz-Oduncuoğlu; Sharon E Mitchell; Mustafa Özilgen; Bayram Yilmaz; John R Speakman

doi:10.1073/pnas.2300624120

A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

Ayşe Selcen Semerciöz-Oduncuoğlu, Sharon E Mitchell, Mustafa Özilgen, Bayram Yilmaz, John R Speakman^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Understanding aging is a key biological goal. Precision gerontology aims to predict how long individuals will live under different treatment scenarios. Calorie and protein restriction (CR and PR) extend lifespan in many species. Using data from C57BL/6 male mice under graded CR or PR, we introduce a computational thermodynamic model for entropy generation, which predicted the impact of the manipulations on lifespan. Daily entropy generation decreased significantly with increasing CR level, but not PR. Our predictions indicated the lifespan of CR mice should increase by 13 to 56% with 10 to 40% CR, relative to ad libitum-fed animals. This prediction was broadly consistent with the empirical observation of the lifespan impacts of CR in rodents. Modeling entropy fluxes may be a future strategy to identify antiaging interventions.

Original language	English
Article number	e2300624120
Number of pages	8
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	120
Issue number	37
Early online date	5 Sept 2023
DOIs	https://doi.org/10.1073/pnas.2300624120
Publication status	Published - 5 Sept 2023

Bibliographical note

Funding Information:
Fellowships and Grant Programs, application number of 1059B141801348. The original experimental study was funded by Biotechnology and Biological Sciences Research Council (BBSRC) BB/G009953/1 and the China Partnering Award BB/J020028/1.

Funding Information:
This research was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK), Science Fellowships and Grant Programs, application number of 1059B141801348. The original experimental study was funded by Biotechnology and Biological Sciences Research Council (BBSRC) BB/G009953/1 and the China Partnering Award BB/J020028/1.

Funding Information:
ACKNOWLEDGMENTS. This research was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK), Science

Data Availability Statement

All the data generated in this work are in the paper or have been previously published.

Keywords

Male
Animals
Mice
Mice, Inbred C57BL
Longevity
Entropy
Diet, Protein-Restricted
Geriatrics

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Cite this

Semerciöz-Oduncuoğlu, A. S., Mitchell, S. E., Özilgen, M., Yilmaz, B., & Speakman, J. R. (2023). A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation. Proceedings of the National Academy of Sciences of the United States of America, 120(37), Article e2300624120. https://doi.org/10.1073/pnas.2300624120

A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation. / Semerciöz-Oduncuoğlu, Ayşe Selcen; Mitchell, Sharon E; Özilgen, Mustafa et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, No. 37, e2300624120, 05.09.2023.

Research output: Contribution to journal › Article › peer-review

Semerciöz-Oduncuoğlu, AS, Mitchell, SE, Özilgen, M, Yilmaz, B & Speakman, JR 2023, 'A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 37, e2300624120. https://doi.org/10.1073/pnas.2300624120

Semerciöz-Oduncuoğlu AS, Mitchell SE, Özilgen M, Yilmaz B, Speakman JR. A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation. Proceedings of the National Academy of Sciences of the United States of America. 2023 Sept 5;120(37):e2300624120. Epub 2023 Sept 5. doi: 10.1073/pnas.2300624120

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A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

Abstract

Bibliographical note

Data Availability Statement

Keywords

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